Anti-tumor Activity of Propofol : A Focus on MicroRNAs
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
BACKGROUND: MicroRNAs are endogenous, short, non-coding RNAs with the length as low as 20 to 25 nucleotides. These RNAs are able to negatively affect the gene expression at the post-transcriptional level. It has been demonstrated that microRNAs play a significant role in cell proliferation, cell migration, cell death, cell differentiation, infection, immune response, and metabolism. Besides, the dysfunction of microRNAs has been observed in a variety of cancers. So, modulation of microRNAs is of interest in the treatment of disorders.
OBJECTIVE: The aim of the current review is to investigate the modulatory effect of propofol on microRNAs in cancer therapy.
METHODS: This review was performed at PubMed, SCOPUS and Web of Science data-bases using keywords "propofol', "microRNA", "cancer therapy", "propofol + microRNA" and "propofol + miR".
RESULTS: It was found that propofol dually down-regulates/upregulates microRNAs to exert its antitumor activity. In terms of oncogenesis microRNAs, propofol exert an inhibitory effect, while propofol significantly enhances the expression of oncosuppressor microRNAs.
CONCLUSION: It seems that propofol is a potential modulator of microRNAs and this capability can be used in the treatment of various cancers.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
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| Enthalten in: |
Current cancer drug targets - 20(2020), 2 vom: 23., Seite 104-114 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ashrafizadeh, Milad [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-tumor activity |
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| Anmerkungen: |
Date Completed 10.05.2021 Date Revised 10.05.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.2174/1568009619666191023100046 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM302624341 |
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| 500 | |a Date Revised 10.05.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a BACKGROUND: MicroRNAs are endogenous, short, non-coding RNAs with the length as low as 20 to 25 nucleotides. These RNAs are able to negatively affect the gene expression at the post-transcriptional level. It has been demonstrated that microRNAs play a significant role in cell proliferation, cell migration, cell death, cell differentiation, infection, immune response, and metabolism. Besides, the dysfunction of microRNAs has been observed in a variety of cancers. So, modulation of microRNAs is of interest in the treatment of disorders | ||
| 520 | |a OBJECTIVE: The aim of the current review is to investigate the modulatory effect of propofol on microRNAs in cancer therapy | ||
| 520 | |a METHODS: This review was performed at PubMed, SCOPUS and Web of Science data-bases using keywords "propofol', "microRNA", "cancer therapy", "propofol + microRNA" and "propofol + miR" | ||
| 520 | |a RESULTS: It was found that propofol dually down-regulates/upregulates microRNAs to exert its antitumor activity. In terms of oncogenesis microRNAs, propofol exert an inhibitory effect, while propofol significantly enhances the expression of oncosuppressor microRNAs | ||
| 520 | |a CONCLUSION: It seems that propofol is a potential modulator of microRNAs and this capability can be used in the treatment of various cancers | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Propofol | |
| 650 | 4 | |a anti-tumor activity | |
| 650 | 4 | |a cancer therapy | |
| 650 | 4 | |a microRNA | |
| 650 | 4 | |a pharmacological targeting | |
| 650 | 4 | |a signaling pathway. | |
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