Molecular Biology and Evolution of Cancer : From Discovery to Action
© The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution..
Cancer progression is an evolutionary process. During this process, evolving cancer cell populations encounter restrictive ecological niches within the body, such as the primary tumor, circulatory system, and diverse metastatic sites. Efforts to prevent or delay cancer evolution-and progression-require a deep understanding of the underlying molecular evolutionary processes. Herein we discuss a suite of concepts and tools from evolutionary and ecological theory that can inform cancer biology in new and meaningful ways. We also highlight current challenges to applying these concepts, and propose ways in which incorporating these concepts could identify new therapeutic modes and vulnerabilities in cancer.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:37 |
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| Enthalten in: |
Molecular biology and evolution - 37(2020), 2 vom: 01. Feb., Seite 320-326 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Somarelli, Jason A [VerfasserIn] |
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| Links: |
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| Themen: |
Cancer |
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| Anmerkungen: |
Date Completed 13.10.2020 Date Revised 10.02.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/molbev/msz242 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Cancer progression is an evolutionary process. During this process, evolving cancer cell populations encounter restrictive ecological niches within the body, such as the primary tumor, circulatory system, and diverse metastatic sites. Efforts to prevent or delay cancer evolution-and progression-require a deep understanding of the underlying molecular evolutionary processes. Herein we discuss a suite of concepts and tools from evolutionary and ecological theory that can inform cancer biology in new and meaningful ways. We also highlight current challenges to applying these concepts, and propose ways in which incorporating these concepts could identify new therapeutic modes and vulnerabilities in cancer | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a cancer | |
| 650 | 4 | |a comparative oncology | |
| 650 | 4 | |a fitness landscapes | |
| 650 | 4 | |a genomics | |
| 650 | 4 | |a metastasis | |
| 650 | 4 | |a tumor phylogenetics | |
| 700 | 1 | |a Gardner, Heather |e verfasserin |4 aut | |
| 700 | 1 | |a Cannataro, Vincent L |e verfasserin |4 aut | |
| 700 | 1 | |a Gunady, Ella F |e verfasserin |4 aut | |
| 700 | 1 | |a Boddy, Amy M |e verfasserin |4 aut | |
| 700 | 1 | |a Johnson, Norman A |e verfasserin |4 aut | |
| 700 | 1 | |a Fisk, Jeffrey Nicholas |e verfasserin |4 aut | |
| 700 | 1 | |a Gaffney, Stephen G |e verfasserin |4 aut | |
| 700 | 1 | |a Chuang, Jeffrey H |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Sheng |e verfasserin |4 aut | |
| 700 | 1 | |a Ciccarelli, Francesca D |e verfasserin |4 aut | |
| 700 | 1 | |a Panchenko, Anna R |e verfasserin |4 aut | |
| 700 | 1 | |a Megquier, Kate |e verfasserin |4 aut | |
| 700 | 1 | |a Kumar, Sudhir |e verfasserin |4 aut | |
| 700 | 1 | |a Dornburg, Alex |e verfasserin |4 aut | |
| 700 | 1 | |a DeGregori, James |e verfasserin |4 aut | |
| 700 | 1 | |a Townsend, Jeffrey P |e verfasserin |4 aut | |
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