New Amine and Aromatic Substituted Analogues of Phencyclidine : Synthesis and Determination of Acute and Chronic Pain Activities
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
BACKGROUND: Phencyclidine (PCP, I) is a synthetic drug with remarkable physiological properties. PCP and its analogues exert many pharmacological activities and interact with some neurotransmitter systems in the central nervous system like particular affinity for PCP sites in NMDA receptors or dopamine uptake blocking or even both.
AIM AND OBJECTIVE: The following research, methyl group with electron-donating and dipole moment characters was added in different positions of phenyl ring along with the substitution of benzylamine (with many pharmacological effects) instead of piperidine ring of I to produce new compounds (II-V) of this family with more analgesic activities.
MATERIALS AND METHODS: Analgesic activities of these new compounds were measured by tail immersion and formalin tests for acute and chronic pains, respectively. Also, the outcomes were compared with control and PCP (10 mg/kg) groups.
RESULTS: The results indicate that compounds III, IV, and V have more acute and chronic antinociceptive effects than PCP and compound II which may be concerned with more antagonizing activities of these new painkillers for the blockage of dopamine reuptake as well as high affinity for NMDA receptors PCP binding site.
CONCLUSION: It can be concluded that the benzylamine derivative of phencyclidine with a methyl group on the benzyl position on phenyl ring (V) is a more appropriate candidate to reduce acute and chronic (thermal and chemical) pains compared to other substituted phenyl analogs (II-IV) and PCP.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
Combinatorial chemistry & high throughput screening - 22(2019), 8 vom: 01., Seite 570-576 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Shokrollahi, Maryam [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 01.09.2020 Date Revised 01.09.2020 published: Print Citation Status MEDLINE |
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| doi: |
10.2174/1386207322666191016152157 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM302285849 |
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| 500 | |a Date Revised 01.09.2020 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a BACKGROUND: Phencyclidine (PCP, I) is a synthetic drug with remarkable physiological properties. PCP and its analogues exert many pharmacological activities and interact with some neurotransmitter systems in the central nervous system like particular affinity for PCP sites in NMDA receptors or dopamine uptake blocking or even both | ||
| 520 | |a AIM AND OBJECTIVE: The following research, methyl group with electron-donating and dipole moment characters was added in different positions of phenyl ring along with the substitution of benzylamine (with many pharmacological effects) instead of piperidine ring of I to produce new compounds (II-V) of this family with more analgesic activities | ||
| 520 | |a MATERIALS AND METHODS: Analgesic activities of these new compounds were measured by tail immersion and formalin tests for acute and chronic pains, respectively. Also, the outcomes were compared with control and PCP (10 mg/kg) groups | ||
| 520 | |a RESULTS: The results indicate that compounds III, IV, and V have more acute and chronic antinociceptive effects than PCP and compound II which may be concerned with more antagonizing activities of these new painkillers for the blockage of dopamine reuptake as well as high affinity for NMDA receptors PCP binding site | ||
| 520 | |a CONCLUSION: It can be concluded that the benzylamine derivative of phencyclidine with a methyl group on the benzyl position on phenyl ring (V) is a more appropriate candidate to reduce acute and chronic (thermal and chemical) pains compared to other substituted phenyl analogs (II-IV) and PCP | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Benzylamine derivatives of phencyclidine | |
| 650 | 4 | |a NMDA receptors | |
| 650 | 4 | |a Tail Immersion tests | |
| 650 | 4 | |a dopamine uptake blocking | |
| 650 | 4 | |a formalin tests | |
| 650 | 4 | |a synthetic drug. | |
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| 700 | 1 | |a Khalili, Mohsen |e verfasserin |4 aut | |
| 700 | 1 | |a Sobhanian, Seyed A |e verfasserin |4 aut | |
| 700 | 1 | |a Ahmadi, Abbas |e verfasserin |4 aut | |
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