Antiretroviral Penetration across Three Preclinical Animal Models and Humans in Eight Putative HIV Viral Reservoirs
Copyright © 2019 American Society for Microbiology..
For HIV cure strategies like "kick and kill" to succeed, antiretroviral (ARV) drugs must reach effective concentrations in putative viral reservoirs. We characterize penetration of six ARVs in three preclinical animal models and humans. We found that standard dosing strategies in preclinical species closely mimicked tissue concentrations in humans for some, but not all, ARVs. These results have implications for interpreting HIV treatment, prevention, or cure interventions between preclinical and clinical models.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:64 |
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| Enthalten in: |
Antimicrobial agents and chemotherapy - 64(2019), 1 vom: 20. Dez. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Devanathan, Aaron S [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 31.08.2020 Date Revised 31.08.2020 published: Electronic-Print Citation Status MEDLINE |
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| doi: |
10.1128/AAC.01639-19 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM302180508 |
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| 520 | |a Copyright © 2019 American Society for Microbiology. | ||
| 520 | |a For HIV cure strategies like "kick and kill" to succeed, antiretroviral (ARV) drugs must reach effective concentrations in putative viral reservoirs. We characterize penetration of six ARVs in three preclinical animal models and humans. We found that standard dosing strategies in preclinical species closely mimicked tissue concentrations in humans for some, but not all, ARVs. These results have implications for interpreting HIV treatment, prevention, or cure interventions between preclinical and clinical models | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a HIV | |
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| 700 | 1 | |a Akkina, Ramesh |e verfasserin |4 aut | |
| 700 | 1 | |a Remling-Mulder, Leila |e verfasserin |4 aut | |
| 700 | 1 | |a Luciw, Paul |e verfasserin |4 aut | |
| 700 | 1 | |a Adamson, Lourdes |e verfasserin |4 aut | |
| 700 | 1 | |a Garcia, J Victor |e verfasserin |4 aut | |
| 700 | 1 | |a Kovarova, Martina |e verfasserin |4 aut | |
| 700 | 1 | |a White, Nicole R |e verfasserin |4 aut | |
| 700 | 1 | |a Schauer, Amanda P |e verfasserin |4 aut | |
| 700 | 1 | |a Blake, Kimberly |e verfasserin |4 aut | |
| 700 | 1 | |a Sykes, Craig |e verfasserin |4 aut | |
| 700 | 1 | |a Burgunder, Erin M |e verfasserin |4 aut | |
| 700 | 1 | |a Srinivas, Nithya |e verfasserin |4 aut | |
| 700 | 1 | |a Rosen, Elias P |e verfasserin |4 aut | |
| 700 | 1 | |a Kashuba, Angela D M |e verfasserin |4 aut | |
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