Identifying residual hotspots and mapping lower respiratory infection morbidity and mortality in African children from 2000 to 2017
Lower respiratory infections (LRIs) are the leading cause of death in children under the age of 5, despite the existence of vaccines against many of their aetiologies. Furthermore, more than half of these deaths occur in Africa. Geospatial models can provide highly detailed estimates of trends subnationally, at the level where implementation of health policies has the greatest impact. We used Bayesian geostatistical modelling to estimate LRI incidence, prevalence and mortality in children under 5 subnationally in Africa for 2000-2017, using surveys covering 1.46 million children and 9,215,000 cases of LRI. Our model reveals large within-country variation in both health burden and its change over time. While reductions in childhood morbidity and mortality due to LRI were estimated for almost every country, we expose a cluster of residual high risk across seven countries, which averages 5.5 LRI deaths per 1,000 children per year. The preventable nature of the vast majority of LRI deaths mandates focused health system efforts in specific locations with the highest burden.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2019 |
|---|---|
| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:4 |
|---|---|
| Enthalten in: |
Nature microbiology - 4(2019), 12 vom: 30. Dez., Seite 2310-2318 |
| Sprache: |
Englisch |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 29.06.2020 Date Revised 17.04.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1038/s41564-019-0562-y |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM301783632 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM301783632 | ||
| 003 | DE-627 | ||
| 005 | 20231225105337.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41564-019-0562-y |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1005.xml |
| 035 | |a (DE-627)NLM301783632 | ||
| 035 | |a (NLM)31570869 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Reiner, Robert C |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Identifying residual hotspots and mapping lower respiratory infection morbidity and mortality in African children from 2000 to 2017 |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 29.06.2020 | ||
| 500 | |a Date Revised 17.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Lower respiratory infections (LRIs) are the leading cause of death in children under the age of 5, despite the existence of vaccines against many of their aetiologies. Furthermore, more than half of these deaths occur in Africa. Geospatial models can provide highly detailed estimates of trends subnationally, at the level where implementation of health policies has the greatest impact. We used Bayesian geostatistical modelling to estimate LRI incidence, prevalence and mortality in children under 5 subnationally in Africa for 2000-2017, using surveys covering 1.46 million children and 9,215,000 cases of LRI. Our model reveals large within-country variation in both health burden and its change over time. While reductions in childhood morbidity and mortality due to LRI were estimated for almost every country, we expose a cluster of residual high risk across seven countries, which averages 5.5 LRI deaths per 1,000 children per year. The preventable nature of the vast majority of LRI deaths mandates focused health system efforts in specific locations with the highest burden | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Welgan, Catherine A |e verfasserin |4 aut | |
| 700 | 1 | |a Casey, Daniel C |e verfasserin |4 aut | |
| 700 | 1 | |a Troeger, Christopher E |e verfasserin |4 aut | |
| 700 | 1 | |a Baumann, Mathew M |e verfasserin |4 aut | |
| 700 | 1 | |a Nguyen, QuynhAnh P |e verfasserin |4 aut | |
| 700 | 1 | |a Swartz, Scott J |e verfasserin |4 aut | |
| 700 | 1 | |a Blacker, Brigette F |e verfasserin |4 aut | |
| 700 | 1 | |a Deshpande, Aniruddha |e verfasserin |4 aut | |
| 700 | 1 | |a Mosser, Jonathan F |e verfasserin |4 aut | |
| 700 | 1 | |a Osgood-Zimmerman, Aaron E |e verfasserin |4 aut | |
| 700 | 1 | |a Earl, Lucas |e verfasserin |4 aut | |
| 700 | 1 | |a Marczak, Laurie B |e verfasserin |4 aut | |
| 700 | 1 | |a Munro, Sandra B |e verfasserin |4 aut | |
| 700 | 1 | |a Miller-Petrie, Molly K |e verfasserin |4 aut | |
| 700 | 1 | |a Rodgers Kemp, Grant |e verfasserin |4 aut | |
| 700 | 1 | |a Frostad, Joseph |e verfasserin |4 aut | |
| 700 | 1 | |a Wiens, Kirsten E |e verfasserin |4 aut | |
| 700 | 1 | |a Lindstedt, Paulina A |e verfasserin |4 aut | |
| 700 | 1 | |a Pigott, David M |e verfasserin |4 aut | |
| 700 | 1 | |a Dwyer-Lindgren, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Ross, Jennifer M |e verfasserin |4 aut | |
| 700 | 1 | |a Burstein, Roy |e verfasserin |4 aut | |
| 700 | 1 | |a Graetz, Nicholas |e verfasserin |4 aut | |
| 700 | 1 | |a Rao, Puja C |e verfasserin |4 aut | |
| 700 | 1 | |a Khalil, Ibrahim A |e verfasserin |4 aut | |
| 700 | 1 | |a Davis Weaver, Nicole |e verfasserin |4 aut | |
| 700 | 1 | |a Ray, Sarah E |e verfasserin |4 aut | |
| 700 | 1 | |a Davis, Ian |e verfasserin |4 aut | |
| 700 | 1 | |a Farag, Tamer |e verfasserin |4 aut | |
| 700 | 1 | |a Brady, Oliver J |e verfasserin |4 aut | |
| 700 | 1 | |a Kraemer, Moritz U G |e verfasserin |4 aut | |
| 700 | 1 | |a Smith, David L |e verfasserin |4 aut | |
| 700 | 1 | |a Bhatt, Samir |e verfasserin |4 aut | |
| 700 | 1 | |a Weiss, Daniel J |e verfasserin |4 aut | |
| 700 | 1 | |a Gething, Peter W |e verfasserin |4 aut | |
| 700 | 1 | |a Kassebaum, Nicholas J |e verfasserin |4 aut | |
| 700 | 1 | |a Mokdad, Ali H |e verfasserin |4 aut | |
| 700 | 1 | |a Murray, Christopher J L |e verfasserin |4 aut | |
| 700 | 1 | |a Hay, Simon I |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature microbiology |d 2016 |g 4(2019), 12 vom: 30. Dez., Seite 2310-2318 |w (DE-627)NLM257483241 |x 2058-5276 |7 nnns |
| 773 | 1 | 8 | |g volume:4 |g year:2019 |g number:12 |g day:30 |g month:12 |g pages:2310-2318 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/s41564-019-0562-y |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 4 |j 2019 |e 12 |b 30 |c 12 |h 2310-2318 | ||