Secukinumab does not impair the immunogenic response to the influenza vaccine in patients
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ..
Objective: To evaluate whether immunological response to influenza vaccination is impaired in patients who are receiving secukinumab.
Patients and methods: Subjects suffering from psoriatic arthritis or ankylosing spondylitis who were receiving treatment with secukinumab and healthy volunteers were included.All participants received seasonal inactivated trivalent influenza vaccine recommended by the WHO in the 2017-2018 northern hemisphere influenza season, which contained an A/Michigan/45/2015 (H1N1)pdm09-like virus, an A/Hong Kong/4801/2014 (H3N2)-like virus and a B/Brisbane/60/2008-like virus.Haemagglutination inhibition was used to evaluate basal antibody (Ab) titres against the three influenza vaccine virus strains just before vaccination and at least 4 weeks after the vaccine administration. Response to vaccine was considered as >4-fold increases in Ab titre.
Results: Thirty subjects, 17 patients and 13 healthy controls, with a follow-up duration of 33±8 days, were analysed. There were no demographic differences between groups. Patients and controls achieved a median of 4.6-fold and 4.0-fold increases, respectively, for anti H1N1 and almost 4.0 (3.7) for patients and 5.3 for controls for anti-B Ab. Both groups presented a poor response against H3N2, with <1.5-fold increase. Seroconversion rates were similar in both groups. Secukinumab did not influence the response to the influenza vaccine (relative risk: 1.09 (95% CI 0.58 to 2.07) for H1N1, RR: 1.53 (95% CI 0.15 to 15.0) for H3N2 and RR: 0.72 (95% CI 0.32 to 1.83) for B strain).
Conclusion: In our study, secukinumab has no effect on the immunogenic response to the influenza vaccine.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
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| Enthalten in: |
RMD open - 5(2019), 2 vom: 01., Seite e001018 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Richi, Patricia [VerfasserIn] |
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| Links: |
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| Themen: |
Ankylosing Spondylitis |
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| Anmerkungen: |
Date Completed 27.04.2020 Date Revised 27.04.2020 published: Electronic-eCollection Citation Status MEDLINE |
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| doi: |
10.1136/rmdopen-2019-001018 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM301728585 |
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| 245 | 1 | 0 | |a Secukinumab does not impair the immunogenic response to the influenza vaccine in patients |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. | ||
| 520 | |a Objective: To evaluate whether immunological response to influenza vaccination is impaired in patients who are receiving secukinumab | ||
| 520 | |a Patients and methods: Subjects suffering from psoriatic arthritis or ankylosing spondylitis who were receiving treatment with secukinumab and healthy volunteers were included.All participants received seasonal inactivated trivalent influenza vaccine recommended by the WHO in the 2017-2018 northern hemisphere influenza season, which contained an A/Michigan/45/2015 (H1N1)pdm09-like virus, an A/Hong Kong/4801/2014 (H3N2)-like virus and a B/Brisbane/60/2008-like virus.Haemagglutination inhibition was used to evaluate basal antibody (Ab) titres against the three influenza vaccine virus strains just before vaccination and at least 4 weeks after the vaccine administration. Response to vaccine was considered as >4-fold increases in Ab titre | ||
| 520 | |a Results: Thirty subjects, 17 patients and 13 healthy controls, with a follow-up duration of 33±8 days, were analysed. There were no demographic differences between groups. Patients and controls achieved a median of 4.6-fold and 4.0-fold increases, respectively, for anti H1N1 and almost 4.0 (3.7) for patients and 5.3 for controls for anti-B Ab. Both groups presented a poor response against H3N2, with <1.5-fold increase. Seroconversion rates were similar in both groups. Secukinumab did not influence the response to the influenza vaccine (relative risk: 1.09 (95% CI 0.58 to 2.07) for H1N1, RR: 1.53 (95% CI 0.15 to 15.0) for H3N2 and RR: 0.72 (95% CI 0.32 to 1.83) for B strain) | ||
| 520 | |a Conclusion: In our study, secukinumab has no effect on the immunogenic response to the influenza vaccine | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Ankylosing Spondylitis | |
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| 700 | 1 | |a de Ory, Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Gutiérrez-Larraya, Rosa |e verfasserin |4 aut | |
| 700 | 1 | |a Casas, Inmaculada |e verfasserin |4 aut | |
| 700 | 1 | |a Jiménez-Díaz, Ana María |e verfasserin |4 aut | |
| 700 | 1 | |a Cava, Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Muñoz-Fernandez, Santiago |e verfasserin |4 aut | |
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