Portal Hypertension : Pathogenesis and Diagnosis
Copyright © 2019 Elsevier Inc. All rights reserved..
Portal hypertension (PH) is an increase in the pressure gradient between portal vein and inferior vena cava. Increased resistance occurs at different levels within the portal venous system, followed by increased portal venous inflow. PH is the main driver of cirrhosis decompensation. Varices on endoscopy or portosystemic collaterals on imaging indicate PH. Although its cause is determined mostly via noninvasive tests, the gold standard to measure portal pressure in cirrhosis and determine its severity is hepatic vein catheterization with determination of the hepatic venous pressure gradient. Measuring portal pressure is essential in proof-of-concept studies of portal pressure-lowering drugs.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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| Enthalten in: |
Clinics in liver disease - 23(2019), 4 vom: 29. Nov., Seite 573-587 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Turco, Laura [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 20.07.2020 Date Revised 20.07.2020 published: Print Citation Status MEDLINE |
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| doi: |
10.1016/j.cld.2019.07.007 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM301708290 |
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| 520 | |a Copyright © 2019 Elsevier Inc. All rights reserved. | ||
| 520 | |a Portal hypertension (PH) is an increase in the pressure gradient between portal vein and inferior vena cava. Increased resistance occurs at different levels within the portal venous system, followed by increased portal venous inflow. PH is the main driver of cirrhosis decompensation. Varices on endoscopy or portosystemic collaterals on imaging indicate PH. Although its cause is determined mostly via noninvasive tests, the gold standard to measure portal pressure in cirrhosis and determine its severity is hepatic vein catheterization with determination of the hepatic venous pressure gradient. Measuring portal pressure is essential in proof-of-concept studies of portal pressure-lowering drugs | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Ascites | |
| 650 | 4 | |a Bleeding | |
| 650 | 4 | |a Cirrhosis | |
| 650 | 4 | |a Gastroesophageal varices | |
| 650 | 4 | |a Hepatic venous pressure gradient | |
| 650 | 4 | |a Liver stiffness | |
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