Effects of Pregnancy and Delivery Methods on Change in Ankylosing Spondylitis Treatment Using the Korean Health Insurance Review and Assessment Service Claims Database
© 2019 The Korean Academy of Medical Sciences..
BACKGROUND: Women with ankylosing spondylitis (AS) show a higher rate of cesarean section (CS) compared with healthy women. In this study, we determined the effects of pregnancy and delivery methods on AS worsening by analyzing prescription patterns.
METHODS: The subjects were women with AS aged 20-49 years listed in the Korean Health Insurance Review and Assessment Service claims database. Change in treatment was defined as change in prescriptions 1-2 years before delivery or 1 year after delivery. We compared change in prescriptions between AS women with delivery or without delivery (1:1 matched). Moreover, we evaluated change in prescriptions according to delivery method among AS women with delivery.
RESULTS: A total of 6,821 women with AS were included. Women in the delivery group (n = 996) were younger and showed less drug use and lower comorbidity rates than those in the no delivery group. Change in prescriptions did not differ between the delivery and no delivery groups (odds ratio [OR], 0.76; 95% confidence interval [CI], 0.56-1.05). Furthermore, the overall change in prescriptions did not significantly differ between vaginal delivery (VD) and CS (OR, 0.72; 95% CI, 0.45-1.14).
CONCLUSION: The rate of change in prescriptions was comparable between AS patients with and without delivery. There was no association between the method of delivery and change in prescription. Therefore, pregnancy and VD may not be the factors associated with AS worsening.
| Errataetall: |
CommentIn: J Korean Med Sci. 2019 Sep 30;34(37):e244. - PMID 31559712 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
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| Enthalten in: |
Journal of Korean medical science - 34(2019), 37 vom: 30. Sept., Seite e238 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lee, Jung Sun [VerfasserIn] |
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| Links: |
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| Themen: |
Adrenal Cortex Hormones |
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| Anmerkungen: |
Date Completed 11.02.2020 Date Revised 25.02.2020 published: Electronic CommentIn: J Korean Med Sci. 2019 Sep 30;34(37):e244. - PMID 31559712 Citation Status MEDLINE |
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| doi: |
10.3346/jkms.2019.34.e238 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM301674051 |
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| 500 | |a published: Electronic | ||
| 500 | |a CommentIn: J Korean Med Sci. 2019 Sep 30;34(37):e244. - PMID 31559712 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2019 The Korean Academy of Medical Sciences. | ||
| 520 | |a BACKGROUND: Women with ankylosing spondylitis (AS) show a higher rate of cesarean section (CS) compared with healthy women. In this study, we determined the effects of pregnancy and delivery methods on AS worsening by analyzing prescription patterns | ||
| 520 | |a METHODS: The subjects were women with AS aged 20-49 years listed in the Korean Health Insurance Review and Assessment Service claims database. Change in treatment was defined as change in prescriptions 1-2 years before delivery or 1 year after delivery. We compared change in prescriptions between AS women with delivery or without delivery (1:1 matched). Moreover, we evaluated change in prescriptions according to delivery method among AS women with delivery | ||
| 520 | |a RESULTS: A total of 6,821 women with AS were included. Women in the delivery group (n = 996) were younger and showed less drug use and lower comorbidity rates than those in the no delivery group. Change in prescriptions did not differ between the delivery and no delivery groups (odds ratio [OR], 0.76; 95% confidence interval [CI], 0.56-1.05). Furthermore, the overall change in prescriptions did not significantly differ between vaginal delivery (VD) and CS (OR, 0.72; 95% CI, 0.45-1.14) | ||
| 520 | |a CONCLUSION: The rate of change in prescriptions was comparable between AS patients with and without delivery. There was no association between the method of delivery and change in prescription. Therefore, pregnancy and VD may not be the factors associated with AS worsening | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Ankylosing Spondylitis | |
| 650 | 4 | |a Delivery, Obstetrics | |
| 650 | 4 | |a Pregnancy | |
| 650 | 7 | |a Adrenal Cortex Hormones |2 NLM | |
| 650 | 7 | |a Anti-Inflammatory Agents, Non-Steroidal |2 NLM | |
| 700 | 1 | |a Oh, Ji Seon |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Ye Jee |e verfasserin |4 aut | |
| 700 | 1 | |a Hong, Seokchan |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Chang Keun |e verfasserin |4 aut | |
| 700 | 1 | |a Yoo, Bin |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Yong Gil |e verfasserin |4 aut | |
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