Association between Toxoplasma gondii infection and thyroid dysfunction : a case-control seroprevalence study
BACKGROUND: The association between Toxoplasma gondii infection and thyroid disease has been poorly studied. Therefore, we sought to determine the association between T. gondii seropositivity and thyroid dysfunction.
METHODS: We performed an age- and gender-matched case-control study of 176 patients suffering from hypothyroidism (n = 161) or hyperthyroidism (n = 15) and 528 control subjects without these diseases in a public hospital in Durango City, Mexico. Anti-Toxoplasma IgG antibodies were determined in sera from cases and controls using a commercially available enzyme-linked immunoassay.
RESULTS: Anti-T. gondii IgG antibodies were found in 11 (6.3%) of 176 patients suffering from thyroid dysfunction and in 48 (9.1%) of 528 control subjects (OR = 0.66; 95% CI: 0.33-1.31; P = 0.23). Stratification by two groups of age (50 years and younger, and 51 year and older) showed that the youngest group of patients with thyroid dysfunction had a significantly lower seroprevalence of T. gondii infection than its age- and gender-matched control group (1/83: 1.2% vs 23/257: 8.6%; OR = 0.12; 95% CI: 0.01-0.93; P = 0.01). This stratification also showed that the youngest group of patients with hypothyroidism had a significantly lower seroprevalence of T. gondii infection than its age- and gender matched control group (0/75: 0% vs 21/233: 9.0%; P = 0.003).
CONCLUSIONS: Our results suggest that thyroid dysfunction is not associated with seropositivity to T. gondii in general; however, in young (50 years or less) patients, a negative association between infection and thyroid dysfunction and hypothyroidism was found. Further research to confirm this negative association is needed.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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| Enthalten in: |
BMC infectious diseases - 19(2019), 1 vom: 18. Sept., Seite 826 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Alvarado-Esquivel, Cosme [VerfasserIn] |
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| Links: |
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| Themen: |
Antibodies, Protozoan |
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| Anmerkungen: |
Date Completed 26.11.2019 Date Revised 25.02.2020 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12879-019-4450-0 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM301418888 |
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| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: The association between Toxoplasma gondii infection and thyroid disease has been poorly studied. Therefore, we sought to determine the association between T. gondii seropositivity and thyroid dysfunction | ||
| 520 | |a METHODS: We performed an age- and gender-matched case-control study of 176 patients suffering from hypothyroidism (n = 161) or hyperthyroidism (n = 15) and 528 control subjects without these diseases in a public hospital in Durango City, Mexico. Anti-Toxoplasma IgG antibodies were determined in sera from cases and controls using a commercially available enzyme-linked immunoassay | ||
| 520 | |a RESULTS: Anti-T. gondii IgG antibodies were found in 11 (6.3%) of 176 patients suffering from thyroid dysfunction and in 48 (9.1%) of 528 control subjects (OR = 0.66; 95% CI: 0.33-1.31; P = 0.23). Stratification by two groups of age (50 years and younger, and 51 year and older) showed that the youngest group of patients with thyroid dysfunction had a significantly lower seroprevalence of T. gondii infection than its age- and gender-matched control group (1/83: 1.2% vs 23/257: 8.6%; OR = 0.12; 95% CI: 0.01-0.93; P = 0.01). This stratification also showed that the youngest group of patients with hypothyroidism had a significantly lower seroprevalence of T. gondii infection than its age- and gender matched control group (0/75: 0% vs 21/233: 9.0%; P = 0.003) | ||
| 520 | |a CONCLUSIONS: Our results suggest that thyroid dysfunction is not associated with seropositivity to T. gondii in general; however, in young (50 years or less) patients, a negative association between infection and thyroid dysfunction and hypothyroidism was found. Further research to confirm this negative association is needed | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Case-control study | |
| 650 | 4 | |a Epidemiology | |
| 650 | 4 | |a Hyperthyroidism | |
| 650 | 4 | |a Hypothyroidism | |
| 650 | 4 | |a Infection | |
| 650 | 4 | |a Mexico | |
| 650 | 4 | |a Seroprevalence | |
| 650 | 4 | |a Toxoplasma gondii | |
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| 700 | 1 | |a Guido-Arreola, Carlos Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Cerrillo-Soto, Sandra Margarita |e verfasserin |4 aut | |
| 700 | 1 | |a Pérez-Álamos, Alma Rosa |e verfasserin |4 aut | |
| 700 | 1 | |a Estrada-Martínez, Sergio |e verfasserin |4 aut | |
| 700 | 1 | |a Gutierrez-Martinez, Verónica Dayali |e verfasserin |4 aut | |
| 700 | 1 | |a Sifuentes-Alvarez, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Ramírez-Valles, Eda Guadalupe |e verfasserin |4 aut | |
| 700 | 1 | |a Contreras-Cisneros, Edith |e verfasserin |4 aut | |
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