Diamine oxidase enzyme : a novel biomarker in respiratory allergy
© 2019 ARS-AAOA, LLC..
BACKGROUND: Well-known allergy tests are used to evaluate and diagnose allergic diseases. The aim of this study was to assess the role of serum level diamine oxidase (DAO) enzyme as a diagnostic marker in respiratory allergy.
METHODS: This case-control study included 40 patients with respiratory allergies (atopic asthma and allergic rhinitis) as well as 40 age- and sex-matched controls. A detailed past medical history of allergy was collected from each participant including family history of allergy. Physical examination, pulmonary function test (PFT) and measurement of serum levels of total immunoglobulin E (IgE) and DAO were performed. Skin-prick test and specific IgE to common aeroallergens were also carried out.
RESULTS: DAO levels were higher in patients than controls. There was a positive correlation between severity of disease and DAO. No significant association was found between DAO level and age, type of respiratory allergy, duration of disease, PFT, eosinophilia, and total IgE. DAO had a high negative predictive value (94.7%) and high sensitivity (97.5%).
CONCLUSION: DAO may be helpful in the assessment of severity and in ruling out respiratory allergy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
International forum of allergy & rhinology - 9(2019), 12 vom: 16. Dez., Seite 1478-1484 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Refaat, Maged M [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 01.06.2020 Date Revised 01.06.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/alr.22426 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM30141145X |
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| 245 | 1 | 0 | |a Diamine oxidase enzyme |b a novel biomarker in respiratory allergy |
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| 500 | |a Date Revised 01.06.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2019 ARS-AAOA, LLC. | ||
| 520 | |a BACKGROUND: Well-known allergy tests are used to evaluate and diagnose allergic diseases. The aim of this study was to assess the role of serum level diamine oxidase (DAO) enzyme as a diagnostic marker in respiratory allergy | ||
| 520 | |a METHODS: This case-control study included 40 patients with respiratory allergies (atopic asthma and allergic rhinitis) as well as 40 age- and sex-matched controls. A detailed past medical history of allergy was collected from each participant including family history of allergy. Physical examination, pulmonary function test (PFT) and measurement of serum levels of total immunoglobulin E (IgE) and DAO were performed. Skin-prick test and specific IgE to common aeroallergens were also carried out | ||
| 520 | |a RESULTS: DAO levels were higher in patients than controls. There was a positive correlation between severity of disease and DAO. No significant association was found between DAO level and age, type of respiratory allergy, duration of disease, PFT, eosinophilia, and total IgE. DAO had a high negative predictive value (94.7%) and high sensitivity (97.5%) | ||
| 520 | |a CONCLUSION: DAO may be helpful in the assessment of severity and in ruling out respiratory allergy | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Ghonaim, Sara S |e verfasserin |4 aut | |
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