Influenza virus seroincidence in a cohort of healthy and high-risk children enrolled in infancy, Bangkok, Thailand
Published by Elsevier Ltd..
BACKGROUND: We measured seroconversion to influenza viruses and incidence of symptomatic influenza virus infection in a cohort of children in Bangkok, Thailand.
METHODS: Children aged ≤6 months were followed for two years for acute respiratory illness (ARI) and had serum specimens taken at 6-month intervals and tested by hemagglutination inhibition (HI) assay. Seroconversion was defined as a >4-fold rise in the HI titers between time points with a titer of >40 in the second specimen. Respiratory swabs were tested by rRT-PCR for influenza. Data were analyzed using generalized linear models.
RESULTS: Of 350 children, 266 (76%, 147 were healthy and 119 were high-risk) had ≥2 serum specimens collected before influenza vaccination. During the 2-year follow-up, 266 children contributed 370 person-years of observation, excluding post-vaccination periods. We identified 32 ARI cases with rRT-PCR-confirmed influenza virus infection (7 infections/100 person-years, 95% confidence interval [CI], 4-11). There were 126 episodes of influenza virus infection, resulting in a seroconversion rate of 35 infections/100 person-years (95% CI, 30-42). Rates in healthy and high-risk children did not differ.
CONCLUSIONS: Influenza virus infection is common during the first two years of life among Thai children. A large proportion of infections may not be detected using the ARI case definition.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2019 |
|---|---|
| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:89 |
|---|---|
| Enthalten in: |
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 89(2019) vom: 10. Dez., Seite 21-26 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Rungrojcharoenkit, Kamonthip [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Influenza |
|---|
| Anmerkungen: |
Date Completed 18.02.2020 Date Revised 18.02.2020 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.ijid.2019.08.022 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM300794002 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM300794002 | ||
| 003 | DE-627 | ||
| 005 | 20231225103305.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ijid.2019.08.022 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1002.xml |
| 035 | |a (DE-627)NLM300794002 | ||
| 035 | |a (NLM)31470089 | ||
| 035 | |a (PII)S1201-9712(19)30348-0 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Rungrojcharoenkit, Kamonthip |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Influenza virus seroincidence in a cohort of healthy and high-risk children enrolled in infancy, Bangkok, Thailand |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 18.02.2020 | ||
| 500 | |a Date Revised 18.02.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Published by Elsevier Ltd. | ||
| 520 | |a BACKGROUND: We measured seroconversion to influenza viruses and incidence of symptomatic influenza virus infection in a cohort of children in Bangkok, Thailand | ||
| 520 | |a METHODS: Children aged ≤6 months were followed for two years for acute respiratory illness (ARI) and had serum specimens taken at 6-month intervals and tested by hemagglutination inhibition (HI) assay. Seroconversion was defined as a >4-fold rise in the HI titers between time points with a titer of >40 in the second specimen. Respiratory swabs were tested by rRT-PCR for influenza. Data were analyzed using generalized linear models | ||
| 520 | |a RESULTS: Of 350 children, 266 (76%, 147 were healthy and 119 were high-risk) had ≥2 serum specimens collected before influenza vaccination. During the 2-year follow-up, 266 children contributed 370 person-years of observation, excluding post-vaccination periods. We identified 32 ARI cases with rRT-PCR-confirmed influenza virus infection (7 infections/100 person-years, 95% confidence interval [CI], 4-11). There were 126 episodes of influenza virus infection, resulting in a seroconversion rate of 35 infections/100 person-years (95% CI, 30-42). Rates in healthy and high-risk children did not differ | ||
| 520 | |a CONCLUSIONS: Influenza virus infection is common during the first two years of life among Thai children. A large proportion of infections may not be detected using the ARI case definition | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Influenza | |
| 650 | 4 | |a Pediatric | |
| 650 | 4 | |a Seroconversion | |
| 650 | 4 | |a Seroincidence | |
| 650 | 4 | |a Thailand | |
| 700 | 1 | |a Kittikraisak, Wanitchaya |e verfasserin |4 aut | |
| 700 | 1 | |a Ditsungnoen, Darunee |e verfasserin |4 aut | |
| 700 | 1 | |a Olsen, Sonja J |e verfasserin |4 aut | |
| 700 | 1 | |a Suntarattiwong, Piyarat |e verfasserin |4 aut | |
| 700 | 1 | |a Chotpitayasunondh, Tawee |e verfasserin |4 aut | |
| 700 | 1 | |a Klungthong, Chonticha |e verfasserin |4 aut | |
| 700 | 1 | |a Yoon, In-Kyu |e verfasserin |4 aut | |
| 700 | 1 | |a Dawood, Fatimah S |e verfasserin |4 aut | |
| 700 | 1 | |a Fernandez, Stefan |e verfasserin |4 aut | |
| 700 | 1 | |a Macareo, Louis |e verfasserin |4 aut | |
| 700 | 1 | |a Lindblade, Kim A |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases |d 1998 |g 89(2019) vom: 10. Dez., Seite 21-26 |w (DE-627)NLM094730857 |x 1878-3511 |7 nnns |
| 773 | 1 | 8 | |g volume:89 |g year:2019 |g day:10 |g month:12 |g pages:21-26 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.ijid.2019.08.022 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 89 |j 2019 |b 10 |c 12 |h 21-26 | ||