Exploration of Copper-Cysteamine Nanoparticles as a New Type of Agents for Antimicrobial Photodynamic Inactivation
Copper-cysteamine (Cu-Cy) nanoparticles (NPs) are a new type of sensitizers that can be activated by UV light, X-rays, microwaves and ultrasound to produce reactive oxygen species for cancer treatment. Here, for the first time, we explored Cu-Cy NPs for bacteria inactivation by treating gram-positive bacteria (methicillin-resistant Staphylococcus aureus and Enterococcus faecalis) and gram-negative bacteria (Escherichia coli and Acinetobacter baumannii), respectively. The results show that Cu-Cy NPs are very effective in killing gram-positive bacteria but are quite limited in killing gram-negative bacteria yet. The major killing mechanism is cell damage by singlet oxygen and Cu-Cy NPs are potential agents for bacteria inactivation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Journal of biomedical nanotechnology - 15(2019), 10 vom: 01. Okt., Seite 2142-2148 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Huang, Liyi [VerfasserIn] |
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| Links: |
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| Themen: |
5UX2SD1KE2 |
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| Anmerkungen: |
Date Completed 05.09.2019 Date Revised 14.02.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.1166/jbn.2019.2829 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM300718500 |
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| 520 | |a Copper-cysteamine (Cu-Cy) nanoparticles (NPs) are a new type of sensitizers that can be activated by UV light, X-rays, microwaves and ultrasound to produce reactive oxygen species for cancer treatment. Here, for the first time, we explored Cu-Cy NPs for bacteria inactivation by treating gram-positive bacteria (methicillin-resistant Staphylococcus aureus and Enterococcus faecalis) and gram-negative bacteria (Escherichia coli and Acinetobacter baumannii), respectively. The results show that Cu-Cy NPs are very effective in killing gram-positive bacteria but are quite limited in killing gram-negative bacteria yet. The major killing mechanism is cell damage by singlet oxygen and Cu-Cy NPs are potential agents for bacteria inactivation | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Zhen, Xiumei |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Han |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Hamblin, Michael R |e verfasserin |4 aut | |
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