Outcomes after Surgical Resection of Hilar Cholangiocarcinoma
OBJECTIVE: To report long term outcomes after surgical resection of hilar cholangiocarcinoma (hCCA).
STUDY DESIGN: Cohort study.
PLACE AND DURATION OF STUDY: Department of Liver Transplant and Hepatopancreaticobiliary Surgery, Shifa International Hospital, Islamabad, Pakistan, from October 2011 to April 2018.
METHODOLOGY: A prospective review of maintained database of patients who underwent surgical resection for hCCA was performed. A total of 24 patients were included. Outcome was assessed, based upon 90-day morbidity and mortality, 5-year recurrence-free survival (RFS) and overall survival (OS).
RESULTS: Median age was 49 (23-73) years. Male to female ratio was 1.4:1. Median CA 19-9 level was 113 (2-1200) U/ml. Nine patients (37.5%) underwent right hepatectomy, six had right trisectionectomy (25%), three had central hepatectomy (12.5%) and left hepatectomy (12.5%) each, while three (12.5%) had other surgical procedures. In addition, two (8.3%) patients required portal vein resection and reconstruction. Median blood loss was 1350 (100-2000) ml. Median ICU stay was 4 (2-13) days, while hospital stay was 10 (6-32) days. Sixteen (66.7%) patients experienced at least one morbidity within 90 days, while 90-day mortality was 1/24 (4.1%). The overall recurrence rate was 6/18 (33.4%) and mortality was 9/18 (50%). The actuarial 5-year RFS was 60% and OS was 39%.
CONCLUSION: hCCA remains a technically challenging surgical problem. Outcomes comparable to international standards can be achieved in experienced centres.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
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| Enthalten in: |
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP - 29(2019), 9 vom: 01. Sept., Seite 874-877 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dar, Faisal Saud [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 06.02.2020 Date Revised 06.02.2020 published: Print Citation Status MEDLINE |
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| doi: |
10.29271/jcpsp.2019.09.874 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM300650434 |
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| 500 | |a Date Revised 06.02.2020 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To report long term outcomes after surgical resection of hilar cholangiocarcinoma (hCCA) | ||
| 520 | |a STUDY DESIGN: Cohort study | ||
| 520 | |a PLACE AND DURATION OF STUDY: Department of Liver Transplant and Hepatopancreaticobiliary Surgery, Shifa International Hospital, Islamabad, Pakistan, from October 2011 to April 2018 | ||
| 520 | |a METHODOLOGY: A prospective review of maintained database of patients who underwent surgical resection for hCCA was performed. A total of 24 patients were included. Outcome was assessed, based upon 90-day morbidity and mortality, 5-year recurrence-free survival (RFS) and overall survival (OS) | ||
| 520 | |a RESULTS: Median age was 49 (23-73) years. Male to female ratio was 1.4:1. Median CA 19-9 level was 113 (2-1200) U/ml. Nine patients (37.5%) underwent right hepatectomy, six had right trisectionectomy (25%), three had central hepatectomy (12.5%) and left hepatectomy (12.5%) each, while three (12.5%) had other surgical procedures. In addition, two (8.3%) patients required portal vein resection and reconstruction. Median blood loss was 1350 (100-2000) ml. Median ICU stay was 4 (2-13) days, while hospital stay was 10 (6-32) days. Sixteen (66.7%) patients experienced at least one morbidity within 90 days, while 90-day mortality was 1/24 (4.1%). The overall recurrence rate was 6/18 (33.4%) and mortality was 9/18 (50%). The actuarial 5-year RFS was 60% and OS was 39% | ||
| 520 | |a CONCLUSION: hCCA remains a technically challenging surgical problem. Outcomes comparable to international standards can be achieved in experienced centres | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Shahzadi, Neelam |e verfasserin |4 aut | |
| 700 | 1 | |a Ainy, Seemab Khalid |e verfasserin |4 aut | |
| 700 | 1 | |a Rana, Atif |e verfasserin |4 aut | |
| 700 | 1 | |a Bhatti, Abu Bakar Hafeez |e verfasserin |4 aut | |
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