Predictors of Malnutrition in Children with Cystic Fibrosis
OBJECTIVE: To determine occurrence of malnutrition in children with cystic fibrosis and identify predictors of malnutrition at time of enrolment and after 2 years of follow up.
DESIGN: Retrospective chart review.
PATIENTS: Cystic fibrosis patients enrolled between 2009-2015 with at least 3 years follow-up.
SETTING: Pediatric chest clinic at a tertiary-care center in northern India.
PROCEDURE: Weight and height were noted at enrolment, and after 1 year and 2 years of follow-up. Clinical details, medications, and pulmonary exacerbations during second year were recorded.
MAIN OUTCOME MEASURE: Occurrence of malnutrition i.e. weight for age Z-score < -2.
RESULTS: 61 medical records were reviewed. Occurrence of malnutrition at baseline, and 1- and 2-year follow-up was 65.5%, 54.1% and 57.3%, respectively. Weight for age Z-score at enrolment significantly correlated with time to diagnosis from onset r=0.015, P=0.029). Weight for age Z-score at 2-year follow-up was significantly associated with steatorrhea (P=0.03), increased frequency of stools (P<0.01) and pulmonary exacerbation (P=0.03) during second year. Linear regression showed significant association between weight for age Z-score at 2 years with steatorrhea and pulmonary exacerbations [r=-0.795 (-1.527, -0.062)] and [r=-0.261 (-0.493, -0.028)]. Pulmonary exacerbations during second and third year had significant correlation with weight for age Z-score at the beginning of respective years (r = -0.219, P=0.015).
CONCLUSIONS: Occurrence of malnutrition is high in children with cystic fibrosis in this region, with uncontrolled fat malabsorption and recurrent respiratory infections being significant risk factors.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:56 |
|---|---|
| Enthalten in: |
Indian pediatrics - 56(2019), 10 vom: 15. Okt., Seite 825-830 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dhochak, Nitin [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 23.04.2020 Date Revised 23.04.2020 published: Print-Electronic Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM300511760 |
|---|
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| 245 | 1 | 0 | |a Predictors of Malnutrition in Children with Cystic Fibrosis |
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| 500 | |a Date Completed 23.04.2020 | ||
| 500 | |a Date Revised 23.04.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To determine occurrence of malnutrition in children with cystic fibrosis and identify predictors of malnutrition at time of enrolment and after 2 years of follow up | ||
| 520 | |a DESIGN: Retrospective chart review | ||
| 520 | |a PATIENTS: Cystic fibrosis patients enrolled between 2009-2015 with at least 3 years follow-up | ||
| 520 | |a SETTING: Pediatric chest clinic at a tertiary-care center in northern India | ||
| 520 | |a PROCEDURE: Weight and height were noted at enrolment, and after 1 year and 2 years of follow-up. Clinical details, medications, and pulmonary exacerbations during second year were recorded | ||
| 520 | |a MAIN OUTCOME MEASURE: Occurrence of malnutrition i.e. weight for age Z-score < -2 | ||
| 520 | |a RESULTS: 61 medical records were reviewed. Occurrence of malnutrition at baseline, and 1- and 2-year follow-up was 65.5%, 54.1% and 57.3%, respectively. Weight for age Z-score at enrolment significantly correlated with time to diagnosis from onset r=0.015, P=0.029). Weight for age Z-score at 2-year follow-up was significantly associated with steatorrhea (P=0.03), increased frequency of stools (P<0.01) and pulmonary exacerbation (P=0.03) during second year. Linear regression showed significant association between weight for age Z-score at 2 years with steatorrhea and pulmonary exacerbations [r=-0.795 (-1.527, -0.062)] and [r=-0.261 (-0.493, -0.028)]. Pulmonary exacerbations during second and third year had significant correlation with weight for age Z-score at the beginning of respective years (r = -0.219, P=0.015) | ||
| 520 | |a CONCLUSIONS: Occurrence of malnutrition is high in children with cystic fibrosis in this region, with uncontrolled fat malabsorption and recurrent respiratory infections being significant risk factors | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Sankar, Jhuma |e verfasserin |4 aut | |
| 700 | 1 | |a Lodha, Rakesh |e verfasserin |4 aut | |
| 700 | 1 | |a Kabra, Sushil K |e verfasserin |4 aut | |
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