Structure elucidation and gene cluster characterization of the O-antigen of Vibrio cholerae O68 containing (2S,4R)-2,4-dihydroxypentanoic acid
Copyright © 2019 Elsevier Ltd. All rights reserved..
The O-polysaccharide (O-antigen, OPS) of Vibrio cholerae O68 was studied using chemical analyses and 1D and 2D NMR spectroscopy. The following structure of the tetrasaccharide repeating unit of the OPS was established: where Dhpa indicates (2S,4R)-2,4-dihydroxypentanoic acid existing mainly in the form of 1,4-lactone. Recently, (2R,4S)- and (2R,4R)-isomers of Dhpa have been found in the OPS of Providencia alcalifaciens O8 and O31, respectively. Functions of genes in the O-antigen gene cluster of Vibrio cholerae O68 were predicted according to the OPS structure established. These data provide a molecular basis for classification of V. cholerae strains.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:484 |
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| Enthalten in: |
Carbohydrate research - 484(2019) vom: 01. Okt., Seite 107766 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Xiaodan [VerfasserIn] |
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| Links: |
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| Themen: |
2,4-Dihydroxypentanoic acid |
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| Anmerkungen: |
Date Completed 07.02.2020 Date Revised 07.02.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.carres.2019.107766 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM300323891 |
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| 245 | 1 | 0 | |a Structure elucidation and gene cluster characterization of the O-antigen of Vibrio cholerae O68 containing (2S,4R)-2,4-dihydroxypentanoic acid |
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| 500 | |a Date Revised 07.02.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019 Elsevier Ltd. All rights reserved. | ||
| 520 | |a The O-polysaccharide (O-antigen, OPS) of Vibrio cholerae O68 was studied using chemical analyses and 1D and 2D NMR spectroscopy. The following structure of the tetrasaccharide repeating unit of the OPS was established: where Dhpa indicates (2S,4R)-2,4-dihydroxypentanoic acid existing mainly in the form of 1,4-lactone. Recently, (2R,4S)- and (2R,4R)-isomers of Dhpa have been found in the OPS of Providencia alcalifaciens O8 and O31, respectively. Functions of genes in the O-antigen gene cluster of Vibrio cholerae O68 were predicted according to the OPS structure established. These data provide a molecular basis for classification of V. cholerae strains | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a 2,4-Dihydroxypentanoic acid | |
| 650 | 4 | |a Bacterial polysaccharide structure | |
| 650 | 4 | |a Lipopolysaccharide | |
| 650 | 4 | |a O-antigen | |
| 650 | 4 | |a O-antigen gene cluster | |
| 650 | 4 | |a Vibrio cholerae | |
| 650 | 7 | |a O Antigens |2 NLM | |
| 650 | 7 | |a Pentanoic Acids |2 NLM | |
| 650 | 7 | |a Polysaccharides, Bacterial |2 NLM | |
| 700 | 1 | |a Perepelov, Andrei V |e verfasserin |4 aut | |
| 700 | 1 | |a Filatov, Andrei V |e verfasserin |4 aut | |
| 700 | 1 | |a Shashkov, Alexander S |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Bin |e verfasserin |4 aut | |
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