Physical exercise improves quality of life, depressive symptoms, and cognition across chronic brain disorders : a transdiagnostic systematic review and meta-analysis of randomized controlled trials
We performed a meta-analysis to synthesize evidence on the efficacy and safety of physical exercise as an add-on therapeutic intervention for quality of life (QoL), depressive symptoms and cognition across six chronic brain disorders: Alzheimer's disease, Huntington's disease, multiple sclerosis, Parkinson's disease, schizophrenia and unipolar depression. 122 studies ( = k) (n = 7231) were included. Exercise was superior to treatment as usual in improving QoL (k = 64, n = 4334, ES = 0.40, p < 0.0001), depressive symptoms (k = 60, n = 2909, ES = 0.78, p < 0.0001), the cognitive domains attention and working memory (k = 21, n = 1313, ES = 0.24, p < 0.009), executive functioning (k = 14, n = 977, ES = 0.15, p = 0.013), memory (k = 12, n = 994, ES = 0.12, p = 0.038) and psychomotor speed (k = 16, n = 896, ES = 0.23, p = 0.003). Meta-regression showed a dose-response effect for exercise time (min/week) on depressive symptoms (β = 0.007, p = 0.012). 69% of the studies that reported on safety, found no complications. Exercise is an efficacious and safe add-on therapeutic intervention showing a medium-sized effect on QoL and a large effect on mood in patients with chronic brain disorders, with a positive dose-response correlation. Exercise also improved several cognitive domains with small but significant effects.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2021 |
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Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:268 |
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Enthalten in: |
Journal of neurology - 268(2021), 4 vom: 14. Apr., Seite 1222-1246 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Dauwan, Meenakshi [VerfasserIn] |
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Links: |
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Themen: |
Alzheimer’s disease |
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Anmerkungen: |
Date Completed 18.06.2021 Date Revised 19.09.2023 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1007/s00415-019-09493-9 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM300245254 |
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520 | |a We performed a meta-analysis to synthesize evidence on the efficacy and safety of physical exercise as an add-on therapeutic intervention for quality of life (QoL), depressive symptoms and cognition across six chronic brain disorders: Alzheimer's disease, Huntington's disease, multiple sclerosis, Parkinson's disease, schizophrenia and unipolar depression. 122 studies ( = k) (n = 7231) were included. Exercise was superior to treatment as usual in improving QoL (k = 64, n = 4334, ES = 0.40, p < 0.0001), depressive symptoms (k = 60, n = 2909, ES = 0.78, p < 0.0001), the cognitive domains attention and working memory (k = 21, n = 1313, ES = 0.24, p < 0.009), executive functioning (k = 14, n = 977, ES = 0.15, p = 0.013), memory (k = 12, n = 994, ES = 0.12, p = 0.038) and psychomotor speed (k = 16, n = 896, ES = 0.23, p = 0.003). Meta-regression showed a dose-response effect for exercise time (min/week) on depressive symptoms (β = 0.007, p = 0.012). 69% of the studies that reported on safety, found no complications. Exercise is an efficacious and safe add-on therapeutic intervention showing a medium-sized effect on QoL and a large effect on mood in patients with chronic brain disorders, with a positive dose-response correlation. Exercise also improved several cognitive domains with small but significant effects | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Meta-Analysis | |
650 | 4 | |a Review | |
650 | 4 | |a Systematic Review | |
650 | 4 | |a Alzheimer’s disease | |
650 | 4 | |a Depression | |
650 | 4 | |a Multiple sclerosis | |
650 | 4 | |a Parkinson’s disease | |
650 | 4 | |a Physical exercise | |
650 | 4 | |a Schizophrenia | |
700 | 1 | |a Begemann, Marieke J H |e verfasserin |4 aut | |
700 | 1 | |a Slot, Margot I E |e verfasserin |4 aut | |
700 | 1 | |a Lee, Edwin H M |e verfasserin |4 aut | |
700 | 1 | |a Scheltens, Philip |e verfasserin |4 aut | |
700 | 1 | |a Sommer, Iris E C |e verfasserin |4 aut | |
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