Bioactive Capnosanes and Cembranes from the Soft Coral Klyxum flaccidum
Two new capnosane-based diterpenoids, flaccidenol A (1) and 7-epi-pavidolide D (2), two new cembranoids, flaccidodioxide (3) and flaccidodiol (4), and three known compounds 5 to 7 were characterized from the marine soft coral Klyxum flaccidum, collected off the coast of the island of Pratas. The structures of the new compounds were determined by extensive spectroscopic analyses, including 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, and spectroscopic data comparison with related structures. The rare capnosane diterpenoids were isolated herein from the genus Klyxum for the first time. The cytotoxicity of compounds 1 to 7 against the proliferation of a limited panel of cancer cell lines was assayed. The isolated diterpenoids also exhibited anti-inflammatory activity through suppression of superoxide anion generation and elastase release in the N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-stimulated human neutrophils. Furthermore, 1 and 7 also exhibited cytotoxicity toward the tested cancer cells, and 7 could effectively inhibit elastase release. It is worth noting that the biological activities of 7 are reported for the first time in this paper.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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| Enthalten in: |
Marine drugs - 17(2019), 8 vom: 07. Aug. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tseng, Wan-Ru [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 15.01.2020 Date Revised 25.02.2020 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3390/md17080461 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM300054955 |
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| 100 | 1 | |a Tseng, Wan-Ru |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Bioactive Capnosanes and Cembranes from the Soft Coral Klyxum flaccidum |
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| 500 | |a Date Revised 25.02.2020 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Two new capnosane-based diterpenoids, flaccidenol A (1) and 7-epi-pavidolide D (2), two new cembranoids, flaccidodioxide (3) and flaccidodiol (4), and three known compounds 5 to 7 were characterized from the marine soft coral Klyxum flaccidum, collected off the coast of the island of Pratas. The structures of the new compounds were determined by extensive spectroscopic analyses, including 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, and spectroscopic data comparison with related structures. The rare capnosane diterpenoids were isolated herein from the genus Klyxum for the first time. The cytotoxicity of compounds 1 to 7 against the proliferation of a limited panel of cancer cell lines was assayed. The isolated diterpenoids also exhibited anti-inflammatory activity through suppression of superoxide anion generation and elastase release in the N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-stimulated human neutrophils. Furthermore, 1 and 7 also exhibited cytotoxicity toward the tested cancer cells, and 7 could effectively inhibit elastase release. It is worth noting that the biological activities of 7 are reported for the first time in this paper | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Klyxum flaccidum | |
| 650 | 4 | |a anti-inflammatory activity | |
| 650 | 4 | |a capnosane | |
| 650 | 4 | |a cembrane | |
| 650 | 4 | |a cytotoxic activity | |
| 650 | 4 | |a soft coral | |
| 650 | 7 | |a Anti-Inflammatory Agents |2 NLM | |
| 650 | 7 | |a Biological Factors |2 NLM | |
| 650 | 7 | |a Diterpenes |2 NLM | |
| 650 | 7 | |a Superoxides |2 NLM | |
| 650 | 7 | |a 11062-77-4 |2 NLM | |
| 650 | 7 | |a Cytochalasin B |2 NLM | |
| 650 | 7 | |a 3CHI920QS7 |2 NLM | |
| 650 | 7 | |a N-Formylmethionine Leucyl-Phenylalanine |2 NLM | |
| 650 | 7 | |a 59880-97-6 |2 NLM | |
| 650 | 7 | |a Pancreatic Elastase |2 NLM | |
| 650 | 7 | |a EC 3.4.21.36 |2 NLM | |
| 700 | 1 | |a Ahmed, Atallah F |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Chiung-Yao |e verfasserin |4 aut | |
| 700 | 1 | |a Tsai, Yi-Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Tai, Chi-Jen |e verfasserin |4 aut | |
| 700 | 1 | |a Orfali, Raha S |e verfasserin |4 aut | |
| 700 | 1 | |a Hwang, Tsong-Long |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yi-Hsuan |e verfasserin |4 aut | |
| 700 | 1 | |a Dai, Chang-Feng |e verfasserin |4 aut | |
| 700 | 1 | |a Sheu, Jyh-Horng |e verfasserin |4 aut | |
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