Peri-tumoral Metallic Implants Reduce the Efficacy of Irreversible Electroporation for the Ablation of Colorectal Liver Metastases
PURPOSE: To evaluate the effect of peri-tumoral metallic implants (MI) on the safety and efficacy of percutaneous irreversible electroporation (IRE) of colorectal liver metastasis (CRLM).
MATERIALS AND METHODS: In this retrospective study, 25 patients (12 women, 13 men; MI: 13, no MI: 12) were treated for 29 CRLM. Patient characteristics, tumor location and size, treatment parameters and the presence of MI were evaluated as determinants of local tumor progression (LTP) with the competing risks model (univariate and multivariate analyses). Patient-specific computer models were created to examine the effect of the MI on the electric field used to induce IRE, probability of cell kill and potential thermal effects.
RESULTS: Patients had a median follow-up of 25 months, during which no IRE-related major complications were reported. Univariate analysis showed that tumor size (> 2 cm), probe spacing (> 20 mm) and the presence of MI (p < 0.05) were significant predictors of time to LTP, but only the latter was found to be an independent predictor on multivariate analysis (sub-hazard ratio = 6.5; [95% CI 1.99, 21.4]; p = 0.002). The absence of peri-tumoral MI was associated with higher progression-free survival at 12 months (92.3% [56.6, 98.9] vs 12.5% [2.1, 32.8]). Computer simulations indicated significant distortions and reduction in electric field strength near MI, which could have contributed to under-treatment of the tumor.
CONCLUSIONS: Peri-tumoral MI increases the risk of treatment failure following IRE of CRLM.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:43 |
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| Enthalten in: |
Cardiovascular and interventional radiology - 43(2020), 1 vom: 01. Jan., Seite 84-93 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cornelis, Francois H [VerfasserIn] |
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| Links: |
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| Themen: |
Colorectal metastasis |
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| Anmerkungen: |
Date Completed 17.04.2020 Date Revised 01.01.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00270-019-02300-y |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM299958736 |
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| 100 | 1 | |a Cornelis, Francois H |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Peri-tumoral Metallic Implants Reduce the Efficacy of Irreversible Electroporation for the Ablation of Colorectal Liver Metastases |
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| 500 | |a Date Completed 17.04.2020 | ||
| 500 | |a Date Revised 01.01.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a PURPOSE: To evaluate the effect of peri-tumoral metallic implants (MI) on the safety and efficacy of percutaneous irreversible electroporation (IRE) of colorectal liver metastasis (CRLM) | ||
| 520 | |a MATERIALS AND METHODS: In this retrospective study, 25 patients (12 women, 13 men; MI: 13, no MI: 12) were treated for 29 CRLM. Patient characteristics, tumor location and size, treatment parameters and the presence of MI were evaluated as determinants of local tumor progression (LTP) with the competing risks model (univariate and multivariate analyses). Patient-specific computer models were created to examine the effect of the MI on the electric field used to induce IRE, probability of cell kill and potential thermal effects | ||
| 520 | |a RESULTS: Patients had a median follow-up of 25 months, during which no IRE-related major complications were reported. Univariate analysis showed that tumor size (> 2 cm), probe spacing (> 20 mm) and the presence of MI (p < 0.05) were significant predictors of time to LTP, but only the latter was found to be an independent predictor on multivariate analysis (sub-hazard ratio = 6.5; [95% CI 1.99, 21.4]; p = 0.002). The absence of peri-tumoral MI was associated with higher progression-free survival at 12 months (92.3% [56.6, 98.9] vs 12.5% [2.1, 32.8]). Computer simulations indicated significant distortions and reduction in electric field strength near MI, which could have contributed to under-treatment of the tumor | ||
| 520 | |a CONCLUSIONS: Peri-tumoral MI increases the risk of treatment failure following IRE of CRLM | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Colorectal metastasis | |
| 650 | 4 | |a Irreversible electroporation | |
| 650 | 4 | |a Liver | |
| 650 | 4 | |a Local tumor progression | |
| 650 | 4 | |a Survival | |
| 650 | 4 | |a computer simulations | |
| 650 | 7 | |a Metals |2 NLM | |
| 700 | 1 | |a Cindrič, Helena |e verfasserin |4 aut | |
| 700 | 1 | |a Kos, Bor |e verfasserin |4 aut | |
| 700 | 1 | |a Fujimori, Masashi |e verfasserin |4 aut | |
| 700 | 1 | |a Petre, Elena N |e verfasserin |4 aut | |
| 700 | 1 | |a Miklavčič, Damijan |e verfasserin |4 aut | |
| 700 | 1 | |a Solomon, Stephen B |e verfasserin |4 aut | |
| 700 | 1 | |a Srimathveeravalli, Govindarajan |e verfasserin |4 aut | |
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