Evaluation of a Novel Collagen Hemostatic Matrix : Comparison of Two Hemostatic Matrices in a Rabbits Jejunal Artery Injury Model
Copyright © 2019 Elsevier Inc. All rights reserved..
BACKGROUND: We evaluated the hemostatic efficacy and immunogenicity of CollaStat compared with FloSeal in a rabbit jejunal artery injury model.
METHODS: A total of 27 experimental rabbits were used in the study. For each hemostatic agent, an injury was created in one of the right angles of the jejunal arteries originating from the vascular arcs. Time to hemostasis was determined after applying manual compression to the wound for 30 s, which was repeated a maximum of three times in cases of persistent bleeding. On postoperative day 7, the concentration of serum antithrombin antibody was measured among agent-treated and nontreated control groups.
RESULTS: The mean time to hemostasis for CollaStat was significantly shorter than for FloSeal (64.0 ± 5.0 versus 84.0 ± 7.8 s; P = 0.040). There were no significant differences in rabbit serum mean anti-thrombin Ab concentration between CollaStat-treated, FloSeal -treated, and the control groups (8.43 ± 0.44 versus 8.18 ± 7.8 versus 9.58 ± 1.11 ng/mL; P = 0.065).
CONCLUSIONS: According to our study, CollaStat was more efficient in achieving hemostasis in a rabbit jejunal artery injury and exhibited nonsignificant immunogenicity compared with FloSeal. These findings suggest that CollaStat has acceptable hemostatic potential for controlling significant arterial bleeding.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:243 |
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| Enthalten in: |
The Journal of surgical research - 243(2019) vom: 02. Nov., Seite 553-559 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kim, Min Jhi [VerfasserIn] |
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| Links: |
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| Themen: |
9007-34-5 |
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| Anmerkungen: |
Date Completed 31.01.2020 Date Revised 31.01.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jss.2019.05.017 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM299929574 |
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| 100 | 1 | |a Kim, Min Jhi |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Evaluation of a Novel Collagen Hemostatic Matrix |b Comparison of Two Hemostatic Matrices in a Rabbits Jejunal Artery Injury Model |
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| 500 | |a Date Completed 31.01.2020 | ||
| 500 | |a Date Revised 31.01.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019 Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: We evaluated the hemostatic efficacy and immunogenicity of CollaStat compared with FloSeal in a rabbit jejunal artery injury model | ||
| 520 | |a METHODS: A total of 27 experimental rabbits were used in the study. For each hemostatic agent, an injury was created in one of the right angles of the jejunal arteries originating from the vascular arcs. Time to hemostasis was determined after applying manual compression to the wound for 30 s, which was repeated a maximum of three times in cases of persistent bleeding. On postoperative day 7, the concentration of serum antithrombin antibody was measured among agent-treated and nontreated control groups | ||
| 520 | |a RESULTS: The mean time to hemostasis for CollaStat was significantly shorter than for FloSeal (64.0 ± 5.0 versus 84.0 ± 7.8 s; P = 0.040). There were no significant differences in rabbit serum mean anti-thrombin Ab concentration between CollaStat-treated, FloSeal -treated, and the control groups (8.43 ± 0.44 versus 8.18 ± 7.8 versus 9.58 ± 1.11 ng/mL; P = 0.065) | ||
| 520 | |a CONCLUSIONS: According to our study, CollaStat was more efficient in achieving hemostasis in a rabbit jejunal artery injury and exhibited nonsignificant immunogenicity compared with FloSeal. These findings suggest that CollaStat has acceptable hemostatic potential for controlling significant arterial bleeding | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Evaluation Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a CollaStat | |
| 650 | 4 | |a FloSeal | |
| 650 | 4 | |a Hemostasis | |
| 650 | 4 | |a Hemostatic agent | |
| 650 | 4 | |a Immunogenicity | |
| 650 | 4 | |a Rabbit model | |
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| 700 | 1 | |a Kim, Jee Soo |e verfasserin |4 aut | |
| 700 | 1 | |a Choe, Jun-Ho |e verfasserin |4 aut | |
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