Matrine-Family Alkaloids : Versatile Precursors for Bioactive Modifications
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
Matrine-family alkaloids as tetracycloquinolizindine analogues from Traditional Chinese Medicine Sophora flavescens Ait, Sophora subprostrata and Sophora alopecuroides L possess various pharmacological activities and have aroused great interests over the past decades. Especially, a lot of matrine derivatives have been designed and synthesized and their biological activities investigated, and encouraging results have continuously been achieved in recent several years. These studies are helpful to develop more potent candidates or therapeutic agents and disclose their molecular targets and mechanisms. This paper reviews recent advances in the bioactive modifications of matrine-family alkaloids from derivatization of the C-13, C-14 or C-15 position, opening D ring, fusing D ring and structural simplification.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:16 |
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| Enthalten in: |
Medicinal chemistry (Shariqah (United Arab Emirates)) - 16(2020), 4 vom: 01., Seite 431-453 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cai, Xiao-Hua [VerfasserIn] |
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| Links: |
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| Themen: |
Alkaloid |
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| Anmerkungen: |
Date Completed 18.01.2021 Date Revised 07.12.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.2174/1573406415666190507121744 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM299894908 |
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| 520 | |a Matrine-family alkaloids as tetracycloquinolizindine analogues from Traditional Chinese Medicine Sophora flavescens Ait, Sophora subprostrata and Sophora alopecuroides L possess various pharmacological activities and have aroused great interests over the past decades. Especially, a lot of matrine derivatives have been designed and synthesized and their biological activities investigated, and encouraging results have continuously been achieved in recent several years. These studies are helpful to develop more potent candidates or therapeutic agents and disclose their molecular targets and mechanisms. This paper reviews recent advances in the bioactive modifications of matrine-family alkaloids from derivatization of the C-13, C-14 or C-15 position, opening D ring, fusing D ring and structural simplification | ||
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