Targeting pteridine reductase 1 and dihydrofolate reductase : the old is a new trend for leishmaniasis drug discovery
Leishmaniasis is one of the major neglected tropical diseases in the world and it is considered endemic in 88 countries. This disease is transmitted by a Leishmania spp. infected sandfly and it may lead to cutaneous or systemic manifestations. The preconized treatment has low efficacy and there are cases of resistance to some drugs. Therefore, the search for new efficient molecular targets that can lead to the preparation of new drugs must be pursued. This review aims to evaluate both Leishmania enzymes PTR1 and DHFR-TS as potential drug targets, highlight their inhibitors and to discuss critically the use of chemoinformatics to elucidate interactions and propose new molecules against these enzymes.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2019 |
|---|---|
| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
|---|---|
| Enthalten in: |
Future medicinal chemistry - 11(2019), 16 vom: 28. Aug., Seite 2107-2130 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
das Neves, Gustavo Machado [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 22.06.2020 Date Revised 22.06.2020 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.4155/fmc-2018-0512 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM299820890 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM299820890 | ||
| 003 | DE-627 | ||
| 005 | 20231225101158.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.4155/fmc-2018-0512 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0999.xml |
| 035 | |a (DE-627)NLM299820890 | ||
| 035 | |a (NLM)31370699 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a das Neves, Gustavo Machado |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Targeting pteridine reductase 1 and dihydrofolate reductase |b the old is a new trend for leishmaniasis drug discovery |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 22.06.2020 | ||
| 500 | |a Date Revised 22.06.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Leishmaniasis is one of the major neglected tropical diseases in the world and it is considered endemic in 88 countries. This disease is transmitted by a Leishmania spp. infected sandfly and it may lead to cutaneous or systemic manifestations. The preconized treatment has low efficacy and there are cases of resistance to some drugs. Therefore, the search for new efficient molecular targets that can lead to the preparation of new drugs must be pursued. This review aims to evaluate both Leishmania enzymes PTR1 and DHFR-TS as potential drug targets, highlight their inhibitors and to discuss critically the use of chemoinformatics to elucidate interactions and propose new molecules against these enzymes | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a dihydrofolate reductase | |
| 650 | 4 | |a folate metabolism | |
| 650 | 4 | |a leishmaniasis | |
| 650 | 4 | |a medicinal chemistry | |
| 650 | 4 | |a molecular modeling | |
| 650 | 4 | |a pteridine reductase 1 | |
| 650 | 7 | |a Antiprotozoal Agents |2 NLM | |
| 650 | 7 | |a Folic Acid Antagonists |2 NLM | |
| 650 | 7 | |a Multienzyme Complexes |2 NLM | |
| 650 | 7 | |a thymidylate synthase-dihydrofolate reductase |2 NLM | |
| 650 | 7 | |a Oxidoreductases |2 NLM | |
| 650 | 7 | |a EC 1.- |2 NLM | |
| 650 | 7 | |a pteridine reductase |2 NLM | |
| 650 | 7 | |a EC 1.1.1.33 |2 NLM | |
| 650 | 7 | |a Tetrahydrofolate Dehydrogenase |2 NLM | |
| 650 | 7 | |a EC 1.5.1.3 |2 NLM | |
| 650 | 7 | |a Thymidylate Synthase |2 NLM | |
| 650 | 7 | |a EC 2.1.1.45 |2 NLM | |
| 700 | 1 | |a Kagami, Luciano P |e verfasserin |4 aut | |
| 700 | 1 | |a Gonçalves, Itamar L |e verfasserin |4 aut | |
| 700 | 1 | |a Eifler-Lima, Vera L |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Future medicinal chemistry |d 2009 |g 11(2019), 16 vom: 28. Aug., Seite 2107-2130 |w (DE-627)NLM194822109 |x 1756-8927 |7 nnns |
| 773 | 1 | 8 | |g volume:11 |g year:2019 |g number:16 |g day:28 |g month:08 |g pages:2107-2130 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.4155/fmc-2018-0512 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 11 |j 2019 |e 16 |b 28 |c 08 |h 2107-2130 | ||