Inactivation of oral biofilms using visible light and water-filtered infrared A radiation and indocyanine green
Aim: To investigate the antimicrobial photodynamic therapy (aPDT) of visible light and water-filtered infrared A radiation in combination with indocyanine green (ICG) on planktonic oral microorganisms as well as on oral biofilm. Methods: The irradiation was conducted for 5 min in combination with ICG. Treatment with chlorhexidine served as a positive control. The number of colony forming units and bacterial vitality were quantified. Results: All tested bacterial strains and salivary bacteria were killed at a level of 3log10. The colony forming units of the initial mature oral biofilms were strongly reduced. The high bactericidal effect of aPDT was confirmed by live/dead staining. Conclusion: The aPDT using visible light and water-filtered infrared A radiation and ICG has the potential to treat periodontitis and peri-implantitis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Future medicinal chemistry - 11(2019), 14 vom: 01. Juli, Seite 1721-1739 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Burchard, Thomas [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 01.06.2020 Date Revised 01.06.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.4155/fmc-2018-0522 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM299798003 |
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| 245 | 1 | 0 | |a Inactivation of oral biofilms using visible light and water-filtered infrared A radiation and indocyanine green |
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| 500 | |a Date Completed 01.06.2020 | ||
| 500 | |a Date Revised 01.06.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Aim: To investigate the antimicrobial photodynamic therapy (aPDT) of visible light and water-filtered infrared A radiation in combination with indocyanine green (ICG) on planktonic oral microorganisms as well as on oral biofilm. Methods: The irradiation was conducted for 5 min in combination with ICG. Treatment with chlorhexidine served as a positive control. The number of colony forming units and bacterial vitality were quantified. Results: All tested bacterial strains and salivary bacteria were killed at a level of 3log10. The colony forming units of the initial mature oral biofilms were strongly reduced. The high bactericidal effect of aPDT was confirmed by live/dead staining. Conclusion: The aPDT using visible light and water-filtered infrared A radiation and ICG has the potential to treat periodontitis and peri-implantitis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
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| 650 | 4 | |a aPDT | |
| 650 | 4 | |a antimicrobial photodynamic therapy | |
| 650 | 4 | |a indocyanine green | |
| 650 | 4 | |a oral biofilm | |
| 650 | 4 | |a visible light and water-filtered infrared A | |
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| 650 | 7 | |a Water |2 NLM | |
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| 700 | 1 | |a Hellwig, Elmar |e verfasserin |4 aut | |
| 700 | 1 | |a Follo, Marie |e verfasserin |4 aut | |
| 700 | 1 | |a Wrbas, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Wittmer, Annette |e verfasserin |4 aut | |
| 700 | 1 | |a Vach, Kirstin |e verfasserin |4 aut | |
| 700 | 1 | |a Al-Ahmad, Ali |e verfasserin |4 aut | |
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