A tumor microenvironment model coupled with a mass spectrometry system to probe the metabolism of drug-loaded nanoparticles
This study describes a novel integrated microfluidic platform with microvessel network channels which are connected to an electrospray ionization-mass spectrometer (ESI-MS), allowing real-time probing of nanoparticle (NP) drug delivery in vascular niche around tumors and understanding the drug delivery efficacy in a realistic tumor microenvironment.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:55 |
|---|---|
| Enthalten in: |
Chemical communications (Cambridge, England) - 55(2019), 69 vom: 22. Aug., Seite 10218-10221 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lin, Ling [VerfasserIn] |
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| Links: |
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| Themen: |
Antineoplastic Agents |
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| Anmerkungen: |
Date Completed 27.08.2019 Date Revised 27.08.2019 published: Print Citation Status MEDLINE |
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| doi: |
10.1039/c9cc04628c |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM299761576 |
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| 520 | |a This study describes a novel integrated microfluidic platform with microvessel network channels which are connected to an electrospray ionization-mass spectrometer (ESI-MS), allowing real-time probing of nanoparticle (NP) drug delivery in vascular niche around tumors and understanding the drug delivery efficacy in a realistic tumor microenvironment | ||
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| 650 | 7 | |a Reactive Oxygen Species |2 NLM | |
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| 700 | 1 | |a Wu, Zengnan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Jin-Ming |e verfasserin |4 aut | |
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