Barbiturate derived amphiphilic homopolymers : synthesis, characterization, self-assembly and anticancer drug delivery
Aim: Our aim was to synthesis and characterization of amphiphilic norbornene-derived thiobarbiturate homopolymers (NDTH 1-4) for drug delivery. Methods: Ring-opening metathesis polymerization technique was used to prepare a series of homopolymers. The hydrophobicity is introduced by increasing the number of carbon chains ([-CH2-]n; n = 1, 2, 3 & 4) in between norbornene backbone and thiobarbiturate species. Results: These vesicular aggregates have been used as anticancer Doxorubicin drug delivery vehicles at the acidic (5.5) and physiological (7.4) pHs. Confocal laser-scanning microscopy has demonstrated that the drug-loaded vesicles are easily internalized into living cells. Conclusion: Amphiphilic norbornene-derived thiobarbiturate homopolymer assemblies showed efficient nanocarrier for effective anticancer drug delivery.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Therapeutic delivery - 10(2019), 7 vom: 01. Juli, Seite 419-431 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mane, Shivshankar R [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 27.07.2020 Date Revised 27.07.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.4155/tde-2019-0031 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM299714381 |
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| 100 | 1 | |a Mane, Shivshankar R |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Barbiturate derived amphiphilic homopolymers |b synthesis, characterization, self-assembly and anticancer drug delivery |
| 264 | 1 | |c 2019 | |
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| 500 | |a Date Completed 27.07.2020 | ||
| 500 | |a Date Revised 27.07.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Aim: Our aim was to synthesis and characterization of amphiphilic norbornene-derived thiobarbiturate homopolymers (NDTH 1-4) for drug delivery. Methods: Ring-opening metathesis polymerization technique was used to prepare a series of homopolymers. The hydrophobicity is introduced by increasing the number of carbon chains ([-CH2-]n; n = 1, 2, 3 & 4) in between norbornene backbone and thiobarbiturate species. Results: These vesicular aggregates have been used as anticancer Doxorubicin drug delivery vehicles at the acidic (5.5) and physiological (7.4) pHs. Confocal laser-scanning microscopy has demonstrated that the drug-loaded vesicles are easily internalized into living cells. Conclusion: Amphiphilic norbornene-derived thiobarbiturate homopolymer assemblies showed efficient nanocarrier for effective anticancer drug delivery | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
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| 650 | 4 | |a amphiphilic polymers | |
| 650 | 4 | |a catalyst | |
| 650 | 4 | |a drug delivery | |
| 650 | 4 | |a ring-opening metathesis polymerization | |
| 650 | 7 | |a Antineoplastic Agents |2 NLM | |
| 650 | 7 | |a Drug Carriers |2 NLM | |
| 650 | 7 | |a Norbornanes |2 NLM | |
| 650 | 7 | |a Polymers |2 NLM | |
| 650 | 7 | |a Thiobarbiturates |2 NLM | |
| 650 | 7 | |a 2-norbornene |2 NLM | |
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| 650 | 7 | |a Doxorubicin |2 NLM | |
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| 700 | 1 | |a Sathyan, Ashlin |e verfasserin |4 aut | |
| 700 | 1 | |a Shunmugam, Raja |e verfasserin |4 aut | |
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