Blood pressure changes after renal denervation are more pronounced in women and nondiabetic patients : findings from the Austrian Transcatheter Renal Denervation Registry
OBJECTIVES: Three recently published sham-controlled studies proved the efficacy of renal denervation (RDN) in hypertensive patients. The study presented here analyzed a nationwide multicentre registry database to clarify which patient subgroups benefit most from radiofrequency RDN.
METHODS: This is a post hoc analysis from the multicentre Austrian Transcatheter Renal Denervation Registry hosted by the Austrian Society of Hypertension. We correlated change of SBP after RDN to sex and presence/absence of comorbidities. Univariable correlation and multiple linear regression analyses were performed.
RESULTS: Two hundred and ninety-one patients (43% women, median age 64 years) undergoing RDN between April 2011 and September 2014 were included in this analysis. Mean baseline ambulatory 24 h BP (systolic/diastolic) was 150 ± 18/89 ± 14 mmHg and mean baseline office BP was 170 ± 16/94 ± 14 mmHg.After RDN, mean ambulatory 24 h BP reduction was 9 ± 19/6 ± 16 mmHg. The following features were associated with a good response to RDN: high baseline systolic ambulatory BP, high baseline diastolic office BP, female sex, absence of diabetes mellitus, and absence of peripheral artery disease. Multivariable analysis identified female sex and absence of diabetes mellitus as strongest predictors for ambulatory BP reduction, although those groups had the lowest baseline ambulatory BP.
DISCUSSION: Ambulatory BP reductions after RDN were substantially more pronounced in female and in nondiabetic patients despite lower baseline BP. It is concluded that in terms of efficacy female patients and nondiabetic patients might benefit more from RDN.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2019 |
|---|---|
| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:37 |
|---|---|
| Enthalten in: |
Journal of hypertension - 37(2019), 11 vom: 01. Nov., Seite 2290-2297 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Zweiker, David [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Journal Article |
|---|
| Anmerkungen: |
Date Completed 06.07.2020 Date Revised 06.07.2020 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1097/HJH.0000000000002190 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM299476243 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM299476243 | ||
| 003 | DE-627 | ||
| 005 | 20231225100422.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1097/HJH.0000000000002190 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0998.xml |
| 035 | |a (DE-627)NLM299476243 | ||
| 035 | |a (NLM)31335512 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Zweiker, David |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Blood pressure changes after renal denervation are more pronounced in women and nondiabetic patients |b findings from the Austrian Transcatheter Renal Denervation Registry |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 06.07.2020 | ||
| 500 | |a Date Revised 06.07.2020 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVES: Three recently published sham-controlled studies proved the efficacy of renal denervation (RDN) in hypertensive patients. The study presented here analyzed a nationwide multicentre registry database to clarify which patient subgroups benefit most from radiofrequency RDN | ||
| 520 | |a METHODS: This is a post hoc analysis from the multicentre Austrian Transcatheter Renal Denervation Registry hosted by the Austrian Society of Hypertension. We correlated change of SBP after RDN to sex and presence/absence of comorbidities. Univariable correlation and multiple linear regression analyses were performed | ||
| 520 | |a RESULTS: Two hundred and ninety-one patients (43% women, median age 64 years) undergoing RDN between April 2011 and September 2014 were included in this analysis. Mean baseline ambulatory 24 h BP (systolic/diastolic) was 150 ± 18/89 ± 14 mmHg and mean baseline office BP was 170 ± 16/94 ± 14 mmHg.After RDN, mean ambulatory 24 h BP reduction was 9 ± 19/6 ± 16 mmHg. The following features were associated with a good response to RDN: high baseline systolic ambulatory BP, high baseline diastolic office BP, female sex, absence of diabetes mellitus, and absence of peripheral artery disease. Multivariable analysis identified female sex and absence of diabetes mellitus as strongest predictors for ambulatory BP reduction, although those groups had the lowest baseline ambulatory BP | ||
| 520 | |a DISCUSSION: Ambulatory BP reductions after RDN were substantially more pronounced in female and in nondiabetic patients despite lower baseline BP. It is concluded that in terms of efficacy female patients and nondiabetic patients might benefit more from RDN | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Lambert, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Steinwender, Clemens |e verfasserin |4 aut | |
| 700 | 1 | |a Weber, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Suppan, Markus |e verfasserin |4 aut | |
| 700 | 1 | |a Brussee, Helmut |e verfasserin |4 aut | |
| 700 | 1 | |a Niederl, Ella |e verfasserin |4 aut | |
| 700 | 1 | |a Koppelstaetter, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Kerschbaum, Julia |e verfasserin |4 aut | |
| 700 | 1 | |a Watschinger, Bruno |e verfasserin |4 aut | |
| 700 | 1 | |a Hohenstein-Scheibenecker, Katharina |e verfasserin |4 aut | |
| 700 | 1 | |a Reindl-Schwaighofer, Roman |e verfasserin |4 aut | |
| 700 | 1 | |a Sturmberger, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Kindslehner, Claudia |e verfasserin |4 aut | |
| 700 | 1 | |a Weiss, Thomas Werner |e verfasserin |4 aut | |
| 700 | 1 | |a Rohla, Miklos |e verfasserin |4 aut | |
| 700 | 1 | |a Gruener, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a Maister, Petra |e verfasserin |4 aut | |
| 700 | 1 | |a Auer, Johann |e verfasserin |4 aut | |
| 700 | 1 | |a Dechant, Cornelia |e verfasserin |4 aut | |
| 700 | 1 | |a Sykora, Josef |e verfasserin |4 aut | |
| 700 | 1 | |a Krismer, Christoph |e verfasserin |4 aut | |
| 700 | 1 | |a Glaser, Stefan |e verfasserin |4 aut | |
| 700 | 1 | |a Zirlik, Andreas |e verfasserin |4 aut | |
| 700 | 1 | |a Zweiker, Robert |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of hypertension |d 1987 |g 37(2019), 11 vom: 01. Nov., Seite 2290-2297 |w (DE-627)NLM01293562X |x 1473-5598 |7 nnns |
| 773 | 1 | 8 | |g volume:37 |g year:2019 |g number:11 |g day:01 |g month:11 |g pages:2290-2297 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1097/HJH.0000000000002190 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 37 |j 2019 |e 11 |b 01 |c 11 |h 2290-2297 | ||