Right ventricular dysfunction in neurologically deceased organ donors : An observational study in a tertiary-care organ donor referral centre
Copyright © 2019. Published by Elsevier Inc..
PURPOSE: Right ventricular RV dysfunction among transplant recipients correlates with transplant outcome, but its frequency in donors is unknown. The purpose of this study was to describe the epidemiology of RV dysfunction in potential heart donors.".
METHODS: In a seven-year retrospective study of potential heart donors, we explored the incidence of RV dysfunction as observed on echocardiography and explored the association of four distinct factors with RV dysfunction: brain injury diagnosis, thoracic trauma, vasopressin infusion and left ventricular (LV) dysfunction.
RESULTS: All 123 potential heart donors underwent echocardiography: 55 had RV dysfunction (44.7%). Fourty-one (33.3%) had LV dysfunction. Isolated RV dysfunction was present in 27 subjects (22%). LV dysfunction was the only factor significantly associated with RV dysfunction (OR = 4.6 (95% CI 1.9-11.4)). We observed no difference in heart acceptance between subjects with or without RV dysfunction.
CONCLUSION: We observed a high frequency of RV dysfunction in a sample of potential heart donors. However, the temporal evolution of RV dysfunction, the hemodynamic predictors of RV dysfunction, as well the link between donor RV dysfunction and recipient outcomes need to be assessed with further prospective studies.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:54 |
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| Enthalten in: |
Journal of critical care - 54(2019) vom: 01. Dez., Seite 37-41 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Frenette, Anne Julie [VerfasserIn] |
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| Links: |
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| Themen: |
Heart donor |
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| Anmerkungen: |
Date Completed 28.07.2020 Date Revised 28.07.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jcrc.2019.07.014 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM299426394 |
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| 100 | 1 | |a Frenette, Anne Julie |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Right ventricular dysfunction in neurologically deceased organ donors |b An observational study in a tertiary-care organ donor referral centre |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 28.07.2020 | ||
| 500 | |a Date Revised 28.07.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019. Published by Elsevier Inc. | ||
| 520 | |a PURPOSE: Right ventricular RV dysfunction among transplant recipients correlates with transplant outcome, but its frequency in donors is unknown. The purpose of this study was to describe the epidemiology of RV dysfunction in potential heart donors." | ||
| 520 | |a METHODS: In a seven-year retrospective study of potential heart donors, we explored the incidence of RV dysfunction as observed on echocardiography and explored the association of four distinct factors with RV dysfunction: brain injury diagnosis, thoracic trauma, vasopressin infusion and left ventricular (LV) dysfunction | ||
| 520 | |a RESULTS: All 123 potential heart donors underwent echocardiography: 55 had RV dysfunction (44.7%). Fourty-one (33.3%) had LV dysfunction. Isolated RV dysfunction was present in 27 subjects (22%). LV dysfunction was the only factor significantly associated with RV dysfunction (OR = 4.6 (95% CI 1.9-11.4)). We observed no difference in heart acceptance between subjects with or without RV dysfunction | ||
| 520 | |a CONCLUSION: We observed a high frequency of RV dysfunction in a sample of potential heart donors. However, the temporal evolution of RV dysfunction, the hemodynamic predictors of RV dysfunction, as well the link between donor RV dysfunction and recipient outcomes need to be assessed with further prospective studies | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Heart donor | |
| 650 | 4 | |a Organ donation | |
| 650 | 4 | |a Right ventricular dysfunction | |
| 700 | 1 | |a Veillette, Charles |e verfasserin |4 aut | |
| 700 | 1 | |a Meade, Maureen |e verfasserin |4 aut | |
| 700 | 1 | |a Poulin, Frederic |e verfasserin |4 aut | |
| 700 | 1 | |a D'Aragon, Frederick |e verfasserin |4 aut | |
| 700 | 1 | |a Albert, Martin |e verfasserin |4 aut | |
| 700 | 1 | |a Marsolais, Pierre |e verfasserin |4 aut | |
| 700 | 1 | |a Williamson, David |e verfasserin |4 aut | |
| 700 | 1 | |a Charbonney, Emmanuel |e verfasserin |4 aut | |
| 700 | 1 | |a Serri, Karim |e verfasserin |4 aut | |
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