Non-enzymatic D-glucose plasmonic optical fiber grating biosensor
Copyright © 2019 Elsevier B.V. All rights reserved..
Saccharide sensors represent a broad research area in the scope of sensing devices and their involvement in the medical diagnosis field is particularly relevant for cancer detection at early stage. In that context, we present a non-enzymatic optical fiber-based sensor that makes use of plasmon-assisted tilted fiber Bragg gratings (TFBGs) functionalized for D-glucose biosensing through polydopamine (PDA)-immobilized concanavalin A (Con A). Our probe allows a live and accurate monitoring of the PDA layer deposition leading improved surface biochemistry. The SPR shift observed was assessed to 3.83 ± 0.05 nm within 20 min for a 2 mg/mL dopamine solution. Tests performed in different D-Glucose solutions have revealed a limit of detection close to 10-7 M with the highest sensitivity in the 10-6 to 10-4 M range. This configuration has the capability to overcome the limitations of current enzyme-based solutions.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2019 |
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Erschienen: |
2019 |
Enthalten in: |
Zur Gesamtaufnahme - volume:142 |
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Enthalten in: |
Biosensors & bioelectronics - 142(2019) vom: 01. Okt., Seite 111506 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Lobry, Maxime [VerfasserIn] |
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Links: |
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Themen: |
11028-71-0 |
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Anmerkungen: |
Date Completed 29.01.2020 Date Revised 29.01.2020 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1016/j.bios.2019.111506 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM299381226 |
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520 | |a Copyright © 2019 Elsevier B.V. All rights reserved. | ||
520 | |a Saccharide sensors represent a broad research area in the scope of sensing devices and their involvement in the medical diagnosis field is particularly relevant for cancer detection at early stage. In that context, we present a non-enzymatic optical fiber-based sensor that makes use of plasmon-assisted tilted fiber Bragg gratings (TFBGs) functionalized for D-glucose biosensing through polydopamine (PDA)-immobilized concanavalin A (Con A). Our probe allows a live and accurate monitoring of the PDA layer deposition leading improved surface biochemistry. The SPR shift observed was assessed to 3.83 ± 0.05 nm within 20 min for a 2 mg/mL dopamine solution. Tests performed in different D-Glucose solutions have revealed a limit of detection close to 10-7 M with the highest sensitivity in the 10-6 to 10-4 M range. This configuration has the capability to overcome the limitations of current enzyme-based solutions | ||
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700 | 1 | |a Loyez, Médéric |e verfasserin |4 aut | |
700 | 1 | |a Debliquy, Marc |e verfasserin |4 aut | |
700 | 1 | |a Chah, Karima |e verfasserin |4 aut | |
700 | 1 | |a David, Mariel |e verfasserin |4 aut | |
700 | 1 | |a Caucheteur, Christophe |e verfasserin |4 aut | |
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