Non-enzymatic D-glucose plasmonic optical fiber grating biosensor

Copyright © 2019 Elsevier B.V. All rights reserved..

Saccharide sensors represent a broad research area in the scope of sensing devices and their involvement in the medical diagnosis field is particularly relevant for cancer detection at early stage. In that context, we present a non-enzymatic optical fiber-based sensor that makes use of plasmon-assisted tilted fiber Bragg gratings (TFBGs) functionalized for D-glucose biosensing through polydopamine (PDA)-immobilized concanavalin A (Con A). Our probe allows a live and accurate monitoring of the PDA layer deposition leading improved surface biochemistry. The SPR shift observed was assessed to 3.83 ± 0.05 nm within 20 min for a 2 mg/mL dopamine solution. Tests performed in different D-Glucose solutions have revealed a limit of detection close to 10-7 M with the highest sensitivity in the 10-6 to 10-4 M range. This configuration has the capability to overcome the limitations of current enzyme-based solutions.

Medienart:

E-Artikel

Erscheinungsjahr:

2019

Erschienen:

2019

Enthalten in:

Zur Gesamtaufnahme - volume:142

Enthalten in:

Biosensors & bioelectronics - 142(2019) vom: 01. Okt., Seite 111506

Sprache:

Englisch

Beteiligte Personen:

Lobry, Maxime [VerfasserIn]
Lahem, Driss [VerfasserIn]
Loyez, Médéric [VerfasserIn]
Debliquy, Marc [VerfasserIn]
Chah, Karima [VerfasserIn]
David, Mariel [VerfasserIn]
Caucheteur, Christophe [VerfasserIn]

Links:

Volltext

Themen:

11028-71-0
Concanavalin A
D-glucose biosensor
Glucose
IY9XDZ35W2
Immobilized Proteins
Indoles
Journal Article
Non-enzymatic
Polydopamine
Polymers
Surface plasmon resonance
Tilted fiber Bragg grating

Anmerkungen:

Date Completed 29.01.2020

Date Revised 29.01.2020

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.bios.2019.111506

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM299381226