Molecular epidemiology and genetic characterization of influenza B virus in Lebanon during 2016-2018
Copyright © 2019 Elsevier B.V. All rights reserved..
BACKGROUND: Influenza B viruses are a major cause of serious acute respiratory infections in humans.
METHODS: Nasopharyngeal swabs were collected from subjects with influenza-like illness during October 2016-June 2018 and screened for influenza A and B. The hemagglutinin (HA) and neuraminidase (NA) genes of the Lebanese influenza B specimens were sequenced and phylogenetically compared with the vaccine strains and specimens from the Eastern Mediterranean Region and Europe.
RESULTS: Influenza A and B viruses co-circulated between October and May and peaked between January and March. During the 2016-2017 season, A/H3N2 (33.4%) and B/Yamagata (29.7%) were the predominantly circulating viruses followed by B/Victoria and A/H1N1pdm09 viruses. During the 2017-2018 season, A/H3N2 (31.5%) and A/H1Npdm09 (29.3%) were most prevalent with co-circulation of B/Yamagata and to a lesser extent B/Victoria viruses. The B/Yamagata specimens belonged to clade-3 while the B/Victoria belonged to clade-1A. None of the analyzed specimens had a mutation known to confer resistance to NA inhibitors (NAIs).
CONCLUSION: Multiple subtypes of influenza co-circulate each year in Lebanon with a peak between January and March. The trivalent vaccine included a B/Victoria strain which mismatched the B/Yamagata lineage that predominated during the study period, highlighting the importance of quadrivalent vaccines.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2019 |
|---|---|
| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:75 |
|---|---|
| Enthalten in: |
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 75(2019) vom: 15. Nov., Seite 103969 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
AlIbrahim, Malak [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Hemagglutinins |
|---|
| Anmerkungen: |
Date Completed 20.04.2020 Date Revised 20.04.2020 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.meegid.2019.103969 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM299380580 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM299380580 | ||
| 003 | DE-627 | ||
| 005 | 20231225100215.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.meegid.2019.103969 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0997.xml |
| 035 | |a (DE-627)NLM299380580 | ||
| 035 | |a (NLM)31325610 | ||
| 035 | |a (PII)S1567-1348(19)30187-X | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a AlIbrahim, Malak |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Molecular epidemiology and genetic characterization of influenza B virus in Lebanon during 2016-2018 |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 20.04.2020 | ||
| 500 | |a Date Revised 20.04.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019 Elsevier B.V. All rights reserved. | ||
| 520 | |a BACKGROUND: Influenza B viruses are a major cause of serious acute respiratory infections in humans | ||
| 520 | |a METHODS: Nasopharyngeal swabs were collected from subjects with influenza-like illness during October 2016-June 2018 and screened for influenza A and B. The hemagglutinin (HA) and neuraminidase (NA) genes of the Lebanese influenza B specimens were sequenced and phylogenetically compared with the vaccine strains and specimens from the Eastern Mediterranean Region and Europe | ||
| 520 | |a RESULTS: Influenza A and B viruses co-circulated between October and May and peaked between January and March. During the 2016-2017 season, A/H3N2 (33.4%) and B/Yamagata (29.7%) were the predominantly circulating viruses followed by B/Victoria and A/H1N1pdm09 viruses. During the 2017-2018 season, A/H3N2 (31.5%) and A/H1Npdm09 (29.3%) were most prevalent with co-circulation of B/Yamagata and to a lesser extent B/Victoria viruses. The B/Yamagata specimens belonged to clade-3 while the B/Victoria belonged to clade-1A. None of the analyzed specimens had a mutation known to confer resistance to NA inhibitors (NAIs) | ||
| 520 | |a CONCLUSION: Multiple subtypes of influenza co-circulate each year in Lebanon with a peak between January and March. The trivalent vaccine included a B/Victoria strain which mismatched the B/Yamagata lineage that predominated during the study period, highlighting the importance of quadrivalent vaccines | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Influenza | |
| 650 | 4 | |a Lebanon | |
| 650 | 4 | |a Phylogenetic analysis | |
| 650 | 4 | |a Surveillance | |
| 650 | 4 | |a Vaccination | |
| 650 | 7 | |a Hemagglutinins |2 NLM | |
| 650 | 7 | |a Influenza Vaccines |2 NLM | |
| 700 | 1 | |a Assaf-Casals, Aia |e verfasserin |4 aut | |
| 700 | 1 | |a Massaad, Elie |e verfasserin |4 aut | |
| 700 | 1 | |a Shaker, Rouba |e verfasserin |4 aut | |
| 700 | 1 | |a Soudani, Nadia |e verfasserin |4 aut | |
| 700 | 1 | |a Fayad, Danielle |e verfasserin |4 aut | |
| 700 | 1 | |a Chamseddine, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Lteif-Khoury, Mireille |e verfasserin |4 aut | |
| 700 | 1 | |a Chmaisse, Ahmad |e verfasserin |4 aut | |
| 700 | 1 | |a Isaac, Imad |e verfasserin |4 aut | |
| 700 | 1 | |a Anan, Hind |e verfasserin |4 aut | |
| 700 | 1 | |a Sadaka, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Radwan, Najwa |e verfasserin |4 aut | |
| 700 | 1 | |a Ghanem, Soha |e verfasserin |4 aut | |
| 700 | 1 | |a Naous, Amal |e verfasserin |4 aut | |
| 700 | 1 | |a Karam, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Andary, Rabih |e verfasserin |4 aut | |
| 700 | 1 | |a Dbaibo, Ghassan |e verfasserin |4 aut | |
| 700 | 1 | |a Zaraket, Hassan |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases |d 2001 |g 75(2019) vom: 15. Nov., Seite 103969 |w (DE-627)NLM125623070 |x 1567-7257 |7 nnns |
| 773 | 1 | 8 | |g volume:75 |g year:2019 |g day:15 |g month:11 |g pages:103969 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.meegid.2019.103969 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 75 |j 2019 |b 15 |c 11 |h 103969 | ||