Sinonasal mucoepidermoid carcinoma : a review of the National Cancer Database
© 2019 ARS-AAOA, LLC..
BACKGROUND: Primary sinonasal mucoepidermoid carcinoma (SN-MEC) is a malignancy arising from seromucinous glands of the nasal cavity and paranasal sinuses. Given its rarity, few large-scale studies have been performed. In this study we describe the incidence and determinants of survival of patients with SN-MEC leveraging the National Cancer Database (NCDB).
METHODS: This was a retrospective, population-based cohort study of patients diagnosed with SN-MEC between 2004 and 2012 within the NCDB. The main outcome measure was overall survival (OS).
RESULTS: A total of 164 patients were identified. The cohort was composed of 47.6% males. Mean age at diagnosis was 59.7 years. The maxillary sinus was the most common primary site, accounting for 45.7% of cases. Eleven percent of patients presented with nodal disease, whereas 2.1% had distant metastases. Stage IV disease was seen in 30.4% of cases. A total of 79.8% of the patients underwent surgery, 61.0% received radiation therapy, and 15.1% had chemotherapy. OS at 1, 2, and 5 years was 83%, 77.0%, and 57%, respectively. On multivariate analysis, Medicaid insurance status (hazard ratio [HR], 7.29; 95% confidence interval [CI], 1.74-30.57), advanced tumor size (HR, 4.94; 95% CI, 1.19-20.5), and advanced nodal disease (N1: HR, 9.48; 95% CI, 1.66-54.23; N2B: HR, 19.3; 95% CI, 1.07-350.64) were associated with worse OS.
CONCLUSION: Mucoepidermoid carcinoma is the most common salivary gland malignancy but a rare sinonasal malignancy, with 5-year survival for SN-MEC approximating 50%. A significant proportion of patients present with advanced disease. Both socioeconomic factors and tumor characteristics are associated with survival.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:9 |
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| Enthalten in: |
International forum of allergy & rhinology - 9(2019), 9 vom: 09. Sept., Seite 1046-1053 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Triantafillou, Vasiliki [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 27.05.2020 Date Revised 27.05.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/alr.22379 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM299275183 |
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| 100 | 1 | |a Triantafillou, Vasiliki |e verfasserin |4 aut | |
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| 520 | |a © 2019 ARS-AAOA, LLC. | ||
| 520 | |a BACKGROUND: Primary sinonasal mucoepidermoid carcinoma (SN-MEC) is a malignancy arising from seromucinous glands of the nasal cavity and paranasal sinuses. Given its rarity, few large-scale studies have been performed. In this study we describe the incidence and determinants of survival of patients with SN-MEC leveraging the National Cancer Database (NCDB) | ||
| 520 | |a METHODS: This was a retrospective, population-based cohort study of patients diagnosed with SN-MEC between 2004 and 2012 within the NCDB. The main outcome measure was overall survival (OS) | ||
| 520 | |a RESULTS: A total of 164 patients were identified. The cohort was composed of 47.6% males. Mean age at diagnosis was 59.7 years. The maxillary sinus was the most common primary site, accounting for 45.7% of cases. Eleven percent of patients presented with nodal disease, whereas 2.1% had distant metastases. Stage IV disease was seen in 30.4% of cases. A total of 79.8% of the patients underwent surgery, 61.0% received radiation therapy, and 15.1% had chemotherapy. OS at 1, 2, and 5 years was 83%, 77.0%, and 57%, respectively. On multivariate analysis, Medicaid insurance status (hazard ratio [HR], 7.29; 95% confidence interval [CI], 1.74-30.57), advanced tumor size (HR, 4.94; 95% CI, 1.19-20.5), and advanced nodal disease (N1: HR, 9.48; 95% CI, 1.66-54.23; N2B: HR, 19.3; 95% CI, 1.07-350.64) were associated with worse OS | ||
| 520 | |a CONCLUSION: Mucoepidermoid carcinoma is the most common salivary gland malignancy but a rare sinonasal malignancy, with 5-year survival for SN-MEC approximating 50%. A significant proportion of patients present with advanced disease. Both socioeconomic factors and tumor characteristics are associated with survival | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a sinonasal mucoepidermoid carcinoma | |
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| 700 | 1 | |a Maina, Ivy W |e verfasserin |4 aut | |
| 700 | 1 | |a Kuan, Edward C |e verfasserin |4 aut | |
| 700 | 1 | |a Kohanski, Michael A |e verfasserin |4 aut | |
| 700 | 1 | |a Tong, Charles C |e verfasserin |4 aut | |
| 700 | 1 | |a Patel, Neil N |e verfasserin |4 aut | |
| 700 | 1 | |a Carey, Ryan M |e verfasserin |4 aut | |
| 700 | 1 | |a Workman, Alan D |e verfasserin |4 aut | |
| 700 | 1 | |a Palmer, James N |e verfasserin |4 aut | |
| 700 | 1 | |a Adappa, Nithin D |e verfasserin |4 aut | |
| 700 | 1 | |a Brant, Jason A |e verfasserin |4 aut | |
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