Improving preparedness to respond to cross-border hepatitis A outbreaks in the European Union/European Economic Area : towards comparable sequencing of hepatitis A virus
IntroductionSequence-based typing of hepatitis A virus (HAV) is important for outbreak detection, investigation and surveillance. In 2013, sequencing was central to resolving a large European Union (EU)-wide outbreak related to frozen berries. However, as the sequenced HAV genome regions were only partly comparable between countries, results were not always conclusive.AimThe objective was to gather information on HAV surveillance and sequencing in EU/European Economic Area (EEA) countries to find ways to harmonise their procedures, for improvement of cross-border outbreak responses.MethodsIn 2014, the European Centre for Disease Prevention and Control (ECDC) conducted a survey on HAV surveillance practices in EU/EEA countries. The survey enquired whether a referral system for confirming primary diagnostics of hepatitis A existed as well as a central collection/storage of hepatitis A cases' samples for typing. Questions on HAV sequencing procedures were also asked. Based on the results, an expert consultation proposed harmonised procedures for cross-border outbreak response, in particular regarding sequencing. In 2016, a follow-up survey assessed uptake of suggested methods.ResultsOf 31 EU/EEA countries, 23 (2014) and 27 (2016) participated. Numbers of countries with central collection and storage of HAV positive samples and of those performing sequencing increased from 12 to 15 and 12 to 14 respectively in 2016, with all countries typing an overlapping fragment of 218 nt. However, variation existed in the sequenced genomic regions and their lengths.ConclusionsWhile HAV sequences in EU/EEA countries are comparable for surveillance, collaboration in sharing and comparing these can be further strengthened.
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E-Artikel |
| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
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Zur Gesamtaufnahme - volume:24 |
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| Enthalten in: |
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin - 24(2019), 28 vom: 01. Juli |
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Englisch |
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Capacity building |
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Date Completed 16.07.2020 Date Revised 15.09.2022 published: Print CommentIn: Euro Surveill. 2019 Nov;24(47):. - PMID 31771700 Citation Status MEDLINE |
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| doi: |
10.2807/1560-7917.ES.2019.24.28.1800397 |
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NLM299245152 |
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| 100 | 1 | |a Enkirch, Theresa |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Improving preparedness to respond to cross-border hepatitis A outbreaks in the European Union/European Economic Area |b towards comparable sequencing of hepatitis A virus |
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| 500 | |a Date Completed 16.07.2020 | ||
| 500 | |a Date Revised 15.09.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a CommentIn: Euro Surveill. 2019 Nov;24(47):. - PMID 31771700 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a IntroductionSequence-based typing of hepatitis A virus (HAV) is important for outbreak detection, investigation and surveillance. In 2013, sequencing was central to resolving a large European Union (EU)-wide outbreak related to frozen berries. However, as the sequenced HAV genome regions were only partly comparable between countries, results were not always conclusive.AimThe objective was to gather information on HAV surveillance and sequencing in EU/European Economic Area (EEA) countries to find ways to harmonise their procedures, for improvement of cross-border outbreak responses.MethodsIn 2014, the European Centre for Disease Prevention and Control (ECDC) conducted a survey on HAV surveillance practices in EU/EEA countries. The survey enquired whether a referral system for confirming primary diagnostics of hepatitis A existed as well as a central collection/storage of hepatitis A cases' samples for typing. Questions on HAV sequencing procedures were also asked. Based on the results, an expert consultation proposed harmonised procedures for cross-border outbreak response, in particular regarding sequencing. In 2016, a follow-up survey assessed uptake of suggested methods.ResultsOf 31 EU/EEA countries, 23 (2014) and 27 (2016) participated. Numbers of countries with central collection and storage of HAV positive samples and of those performing sequencing increased from 12 to 15 and 12 to 14 respectively in 2016, with all countries typing an overlapping fragment of 218 nt. However, variation existed in the sequenced genomic regions and their lengths.ConclusionsWhile HAV sequences in EU/EEA countries are comparable for surveillance, collaboration in sharing and comparing these can be further strengthened | ||
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| 650 | 4 | |a HAV | |
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| 650 | 4 | |a foodborne diseases | |
| 650 | 4 | |a hepatitis A virus | |
| 650 | 4 | |a sequence analysis | |
| 650 | 4 | |a surveys and questionnaires | |
| 650 | 7 | |a RNA, Viral |2 NLM | |
| 700 | 1 | |a Severi, Ettore |e verfasserin |4 aut | |
| 700 | 1 | |a Vennema, Harry |e verfasserin |4 aut | |
| 700 | 1 | |a Thornton, Lelia |e verfasserin |4 aut | |
| 700 | 1 | |a Dean, Jonathan |e verfasserin |4 aut | |
| 700 | 1 | |a Borg, Maria-Louise |e verfasserin |4 aut | |
| 700 | 1 | |a Ciccaglione, Anna Rita |e verfasserin |4 aut | |
| 700 | 1 | |a Bruni, Roberto |e verfasserin |4 aut | |
| 700 | 1 | |a Christova, Iva |e verfasserin |4 aut | |
| 700 | 1 | |a Ngui, Siew Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Balogun, Koye |e verfasserin |4 aut | |
| 700 | 1 | |a Němeček, Vratislav |e verfasserin |4 aut | |
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| 700 | 1 | |a Poljak, Mario |e verfasserin |4 aut | |
| 700 | 1 | |a Vold, Line |e verfasserin |4 aut | |
| 700 | 1 | |a Stene-Johansen, Kathrine |e verfasserin |4 aut | |
| 700 | 1 | |a Midgley, Sofie |e verfasserin |4 aut | |
| 700 | 1 | |a Fischer, Thea Kølsen |e verfasserin |4 aut | |
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