2-(Bipiperidin-1-yl)-5-(nitroaryl)-1,3,4-thiadiazoles : Synthesis, evaluation of in vitro leishmanicidal activity, and mechanism of action
Copyright © 2019 Elsevier Ltd. All rights reserved..
The development of novel leishmanicidal agents that are capable of being replaced by the available therapeutic options has become a priority. In the present study, the synthesis and leishmanicidal activity of a series of 5-(nitroheteroaryl-2-yl)-1,3,4-thiadiazole derivatives are described. All compounds appeared to be potent anti-leishmanial agents against both promastigote and amastigote forms of Leishmania major (L. major). Amongst the synthesized compounds, 2-([1,4'-bipiperidin]-1'-yl)-5-(5-nitrofuran-2-yl)-1,3,4-thiadiazole (IIa) and 1-(5-(1-methyl-5-nitro-1H-imidazole-2-yl)-1,3,4-thiadiazol-2-yl)-4-(piperidine-1-yl) piperidine (IIc) are the most effective. Infection index was statistically declined in the presence of all compounds. The analysis of redox-related factors revealed that exposure of L. major cells to IIa and IIc led to an increase in reactive oxygen species (ROS). Furthermore, two compounds were able to increase ROS and NO levels in infected macrophages in a dose-independent manner. In addition, we showed that these compounds induced cell death in promastigotes. Altogether, our results indicated the anti-leishmanial potential of IIa and IIc is mediated by apoptosis through an imbalance in the redox system resulting in the elevation of ROS. This new class of compound seems to hold great promise for the development of new and useful anti-leishmanial agents.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2019 |
---|---|
Erschienen: |
2019 |
Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
---|---|
Enthalten in: |
Bioorganic & medicinal chemistry - 27(2019), 16 vom: 15. Aug., Seite 3682-3691 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Mojallal-Tabatabaei, Zahra [VerfasserIn] |
---|
Links: |
---|
Themen: |
1,3,4-Thiadiazole |
---|
Anmerkungen: |
Date Completed 15.09.2020 Date Revised 15.09.2020 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.bmc.2019.07.009 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM299134032 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM299134032 | ||
003 | DE-627 | ||
005 | 20231225095700.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2019 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.bmc.2019.07.009 |2 doi | |
028 | 5 | 2 | |a pubmed24n0997.xml |
035 | |a (DE-627)NLM299134032 | ||
035 | |a (NLM)31300318 | ||
035 | |a (PII)S0968-0896(19)30370-0 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Mojallal-Tabatabaei, Zahra |e verfasserin |4 aut | |
245 | 1 | 0 | |a 2-(Bipiperidin-1-yl)-5-(nitroaryl)-1,3,4-thiadiazoles |b Synthesis, evaluation of in vitro leishmanicidal activity, and mechanism of action |
264 | 1 | |c 2019 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 15.09.2020 | ||
500 | |a Date Revised 15.09.2020 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2019 Elsevier Ltd. All rights reserved. | ||
520 | |a The development of novel leishmanicidal agents that are capable of being replaced by the available therapeutic options has become a priority. In the present study, the synthesis and leishmanicidal activity of a series of 5-(nitroheteroaryl-2-yl)-1,3,4-thiadiazole derivatives are described. All compounds appeared to be potent anti-leishmanial agents against both promastigote and amastigote forms of Leishmania major (L. major). Amongst the synthesized compounds, 2-([1,4'-bipiperidin]-1'-yl)-5-(5-nitrofuran-2-yl)-1,3,4-thiadiazole (IIa) and 1-(5-(1-methyl-5-nitro-1H-imidazole-2-yl)-1,3,4-thiadiazol-2-yl)-4-(piperidine-1-yl) piperidine (IIc) are the most effective. Infection index was statistically declined in the presence of all compounds. The analysis of redox-related factors revealed that exposure of L. major cells to IIa and IIc led to an increase in reactive oxygen species (ROS). Furthermore, two compounds were able to increase ROS and NO levels in infected macrophages in a dose-independent manner. In addition, we showed that these compounds induced cell death in promastigotes. Altogether, our results indicated the anti-leishmanial potential of IIa and IIc is mediated by apoptosis through an imbalance in the redox system resulting in the elevation of ROS. This new class of compound seems to hold great promise for the development of new and useful anti-leishmanial agents | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a 1,3,4-Thiadiazole | |
650 | 4 | |a Anti-leishmanial activity | |
650 | 4 | |a Leishmania major | |
650 | 4 | |a Redox system | |
650 | 7 | |a Antiprotozoal Agents |2 NLM | |
650 | 7 | |a Thiadiazoles |2 NLM | |
650 | 7 | |a 1,3,4-thiadiazole |2 NLM | |
650 | 7 | |a 14IAC3GH7G |2 NLM | |
700 | 1 | |a Foroumadi, Parham |e verfasserin |4 aut | |
700 | 1 | |a Toolabi, Mahsa |e verfasserin |4 aut | |
700 | 1 | |a Goli, Fereshteh |e verfasserin |4 aut | |
700 | 1 | |a Moghimi, Setareh |e verfasserin |4 aut | |
700 | 1 | |a Kaboudanian-Ardestani, Sussan |e verfasserin |4 aut | |
700 | 1 | |a Foroumadi, Alireza |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Bioorganic & medicinal chemistry |d 1994 |g 27(2019), 16 vom: 15. Aug., Seite 3682-3691 |w (DE-627)NLM074978543 |x 1464-3391 |7 nnns |
773 | 1 | 8 | |g volume:27 |g year:2019 |g number:16 |g day:15 |g month:08 |g pages:3682-3691 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.bmc.2019.07.009 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 27 |j 2019 |e 16 |b 15 |c 08 |h 3682-3691 |