Prophylactic Vitamin K Administration in Neonates on Prolonged Antibiotic Therapy : A Randomized Controlled Trial
OBJECTIVE: To compare the prevalence of vitamin K deficiency after intramuscular vitamin K or no treatment in neonates with sepsis on prolonged (>7 days) antibiotic therapy.
STUDY DESIGN: Open label randomized controlled trial.
SETTING: Level 3 Neonatal Intensive Care Unit (NICU).
PARTICIPANTS: Neonates with first episode of sepsis on antibiotics for ≥7 days were included. Neonates with clinical bleeding, vitamin K prior to start of antibiotic therapy (except the birth dose), cholestasis or prenatally diagnosed bleeding disorder were excluded.
INTERVENTIONS: Randomized to receive 1 mg vitamin K (n=41) or no vitamin K (n=39) on the 7th day of antibiotic therapy.
MAIN OUTCOME MEASURES: Vitamin K deficiency defined as Protein Induced by Vitamin K Absence (PIVKA-II) >>2 ng/mL after 7 ± 2 days of enrolment.
RESULTS: The prevalence of vitamin K deficiency was 100% (n=80) at enrolment and it remained 100% even after 7 ± 2 days of enrolment in both the groups.
CONCLUSIONS: Neonates receiving prolonged antibiotics have universal biochemical vitamin K deficiency despite vitamin K administration on 7th day of antibiotic therapy.
| Errataetall: |
CommentIn: Indian Pediatr. 2019 Jun 15;56(6):459-460. - PMID 31278222 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2019 |
|---|---|
| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:56 |
|---|---|
| Enthalten in: |
Indian pediatrics - 56(2019), 6 vom: 15. Juni, Seite 463-467 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Sethi, Amanpreet [VerfasserIn] |
|---|
| Themen: |
12001-79-5 |
|---|
| Anmerkungen: |
Date Completed 04.02.2020 Date Revised 04.02.2020 published: Print CTRI: CTRI/2017/02/007776 CommentIn: Indian Pediatr. 2019 Jun 15;56(6):459-460. - PMID 31278222 Citation Status MEDLINE |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
NLM298916851 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM298916851 | ||
| 003 | DE-627 | ||
| 005 | 20231225095217.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2019 xx |||||o 00| ||eng c | ||
| 028 | 5 | 2 | |a pubmed24n0996.xml |
| 035 | |a (DE-627)NLM298916851 | ||
| 035 | |a (NLM)31278224 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Sethi, Amanpreet |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prophylactic Vitamin K Administration in Neonates on Prolonged Antibiotic Therapy |b A Randomized Controlled Trial |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 04.02.2020 | ||
| 500 | |a Date Revised 04.02.2020 | ||
| 500 | |a published: Print | ||
| 500 | |a CTRI: CTRI/2017/02/007776 | ||
| 500 | |a CommentIn: Indian Pediatr. 2019 Jun 15;56(6):459-460. - PMID 31278222 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To compare the prevalence of vitamin K deficiency after intramuscular vitamin K or no treatment in neonates with sepsis on prolonged (>7 days) antibiotic therapy | ||
| 520 | |a STUDY DESIGN: Open label randomized controlled trial | ||
| 520 | |a SETTING: Level 3 Neonatal Intensive Care Unit (NICU) | ||
| 520 | |a PARTICIPANTS: Neonates with first episode of sepsis on antibiotics for ≥7 days were included. Neonates with clinical bleeding, vitamin K prior to start of antibiotic therapy (except the birth dose), cholestasis or prenatally diagnosed bleeding disorder were excluded | ||
| 520 | |a INTERVENTIONS: Randomized to receive 1 mg vitamin K (n=41) or no vitamin K (n=39) on the 7th day of antibiotic therapy | ||
| 520 | |a MAIN OUTCOME MEASURES: Vitamin K deficiency defined as Protein Induced by Vitamin K Absence (PIVKA-II) >>2 ng/mL after 7 ± 2 days of enrolment | ||
| 520 | |a RESULTS: The prevalence of vitamin K deficiency was 100% (n=80) at enrolment and it remained 100% even after 7 ± 2 days of enrolment in both the groups | ||
| 520 | |a CONCLUSIONS: Neonates receiving prolonged antibiotics have universal biochemical vitamin K deficiency despite vitamin K administration on 7th day of antibiotic therapy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 7 | |a Anti-Bacterial Agents |2 NLM | |
| 650 | 7 | |a Vitamins |2 NLM | |
| 650 | 7 | |a Vitamin K |2 NLM | |
| 650 | 7 | |a 12001-79-5 |2 NLM | |
| 700 | 1 | |a Sankar, M Jeeva |e verfasserin |4 aut | |
| 700 | 1 | |a Thukral, Anu |e verfasserin |4 aut | |
| 700 | 1 | |a Saxena, Renu |e verfasserin |4 aut | |
| 700 | 1 | |a Chaurasia, Suman |e verfasserin |4 aut | |
| 700 | 1 | |a Agarwal, Ramesh |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Indian pediatrics |d 1964 |g 56(2019), 6 vom: 15. Juni, Seite 463-467 |w (DE-627)NLM000375144 |x 0974-7559 |7 nnns |
| 773 | 1 | 8 | |g volume:56 |g year:2019 |g number:6 |g day:15 |g month:06 |g pages:463-467 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 56 |j 2019 |e 6 |b 15 |c 06 |h 463-467 | ||