Progress Toward Long-Term Survivors of Glioblastoma

Copyright © 2019 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved..

OBJECTIVE: To identify the frequency and characteristics of long-term survivors of glioblastoma.

PATIENTS AND METHODS: Using all cases of glioblastoma with histopathological confirmation in the National Cancer Database from January 1, 2004, through December 31, 2009, clinical, institutional, and treatment-related factors were evaluated with multivariable logistic regression models so as to elucidate factors independently associated with higher than 5-year overall survival after diagnosis.

RESULTS: A total of 48,652 patients met the inclusion criteria, with 2249 (4.6%) achieving 5-year survival. Factors associated with odds of improved 5-year overall survival in multivariable analysis were younger age, female sex, less medical comorbidities, nonwhite race, highest median income quartile, left-sided tumors and tumors outside the brainstem, and treatment with radiotherapy (P<.05 for all). The percentage of patients surviving 5 years remained relatively unchanged over the 6-year study period (P=.97).

CONCLUSION: Despite improvements in median and short-term overall survival shown in recent large clinical trials for glioblastoma, the percentage of patients with glioblastoma achieving 5-year overall survival remains low. This observation calls for the development of practice-redefining therapies and justifies the increased application of radical novel and experimental treatment paradigms for all patients with glioblastoma.

Medienart:

E-Artikel

Erscheinungsjahr:

2019

Erschienen:

2019

Enthalten in:

Zur Gesamtaufnahme - volume:94

Enthalten in:

Mayo Clinic proceedings - 94(2019), 7 vom: 15. Juli, Seite 1278-1286

Sprache:

Englisch

Beteiligte Personen:

Cantrell, J Nathan [VerfasserIn]
Waddle, Mark R [VerfasserIn]
Rotman, Maarten [VerfasserIn]
Peterson, Jennifer L [VerfasserIn]
Ruiz-Garcia, Henry [VerfasserIn]
Heckman, Michael G [VerfasserIn]
Quiñones-Hinojosa, Alfredo [VerfasserIn]
Rosenfeld, Steven S [VerfasserIn]
Brown, Paul D [VerfasserIn]
Trifiletti, Daniel M [VerfasserIn]

Links:

Volltext

Themen:

Journal Article
Observational Study

Anmerkungen:

Date Completed 09.01.2020

Date Revised 14.05.2022

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.mayocp.2018.11.031

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM298449498