Structure and Function of Angiopoietin-like Protein 3 (ANGPTL3) in Atherosclerosis
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
BACKGROUND: Angiopoietin-Like Proteins (ANGPTLs) are structurally related to the angiopoietins. A total of eight ANGPTLs (from ANGPTL1 to ANGPTL8) have been identified so far. Most ANGPTLs possess multibiological functions on lipid metabolism, atherosclerosis, and cancer. Among them, ANGPTL3 has been shown to regulate the levels of Very Low-Density Lipoprotein (VLDL) made by the liver and play a crucial role in human lipoprotein metabolism.
METHOD: A systematic appraisal of ANGPTLs was conducted, focusing on the main features of ANGPTL3 that has a significant role in atherosclerosis.
RESULTS: Angiopoietins including ANGPTL3 are vascular growth factors that are highly specific for endothelial cells, perform a variety of other regulatory activities to influence inflammation, and have been shown to possess both pro-atherosclerotic and atheroprotective effects.
CONCLUSION: ANGPTL3 has been demonstrated as a promising target in the pharmacological management of atherosclerosis. However, many questions remain about its biological functions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
Current medicinal chemistry - 27(2020), 31 vom: 01., Seite 5159-5174 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lu, Xinjie [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 25.09.2020 Date Revised 04.12.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.2174/0929867326666190621120523 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a Date Revised 04.12.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a BACKGROUND: Angiopoietin-Like Proteins (ANGPTLs) are structurally related to the angiopoietins. A total of eight ANGPTLs (from ANGPTL1 to ANGPTL8) have been identified so far. Most ANGPTLs possess multibiological functions on lipid metabolism, atherosclerosis, and cancer. Among them, ANGPTL3 has been shown to regulate the levels of Very Low-Density Lipoprotein (VLDL) made by the liver and play a crucial role in human lipoprotein metabolism | ||
| 520 | |a METHOD: A systematic appraisal of ANGPTLs was conducted, focusing on the main features of ANGPTL3 that has a significant role in atherosclerosis | ||
| 520 | |a RESULTS: Angiopoietins including ANGPTL3 are vascular growth factors that are highly specific for endothelial cells, perform a variety of other regulatory activities to influence inflammation, and have been shown to possess both pro-atherosclerotic and atheroprotective effects | ||
| 520 | |a CONCLUSION: ANGPTL3 has been demonstrated as a promising target in the pharmacological management of atherosclerosis. However, many questions remain about its biological functions | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Angiopoietin-Like Protein (ANGPTL) | |
| 650 | 4 | |a Growth factors | |
| 650 | 4 | |a LDLReceptor (LDLR) | |
| 650 | 4 | |a atherosclerosis | |
| 650 | 4 | |a inflammation | |
| 650 | 4 | |a lipid | |
| 650 | 7 | |a ANGPTL3 protein, human |2 NLM | |
| 650 | 7 | |a ANGPTL8 protein, human |2 NLM | |
| 650 | 7 | |a Angiopoietin-Like Protein 3 |2 NLM | |
| 650 | 7 | |a Angiopoietin-Like Protein 8 |2 NLM | |
| 650 | 7 | |a Angiopoietin-like Proteins |2 NLM | |
| 650 | 7 | |a Angiopoietins |2 NLM | |
| 650 | 7 | |a Peptide Hormones |2 NLM | |
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