Lifespan normative data on rates of brain volume changes
Copyright © 2019. Published by Elsevier Inc..
We provide here normative values of yearly percentage brain volume change (PBVC/y) as obtained with Structural Imaging Evaluation, using Normalization, of Atrophy, a widely used open-source software, developing a PBVC/y calculator for assessing the deviation from the expected PBVC/y in patients with neurological disorders. We assessed multicenter (34 centers, 11 acquisition protocols) magnetic resonance imaging data of 720 healthy participants covering the whole adult lifespan (16-90 years). Data of 421 participants with a follow-up > 6 months were used to obtain the normative values for PBVC/y and data of 392 participants with a follow-up <1 month were selected to assess the intrasubject variability of the brain volume measurement. A mixed model evaluated PBVC/y dependence on age, sex, and magnetic resonance imaging parameters (scan vendor and magnetic field strength). PBVC/y was associated with age (p < 0.001), with 60- to 70-year-old participants showing twice more volume decrease than participants aged 30-40 years. PBVC/y was also associated with magnetic field strength, with higher decreases when measured by 1.5T than 3T scanners (p < 0.001). The variability of PBVC/y normative percentiles was narrower as the interscan interval was longer (e.g., 80th normative percentile was 50% smaller for participants with 2-year than with 1-year follow-up). The use of these normative data, eased by the freely available calculator, might help in better discriminating pathological from physiological conditions in the clinical setting.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:81 |
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| Enthalten in: |
Neurobiology of aging - 81(2019) vom: 15. Sept., Seite 30-37 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Battaglini, Marco [VerfasserIn] |
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| Links: |
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| Themen: |
Aging |
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| Anmerkungen: |
Date Completed 06.05.2020 Date Revised 06.05.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.neurobiolaging.2019.05.010 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM29823954X |
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| 245 | 1 | 0 | |a Lifespan normative data on rates of brain volume changes |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019. Published by Elsevier Inc. | ||
| 520 | |a We provide here normative values of yearly percentage brain volume change (PBVC/y) as obtained with Structural Imaging Evaluation, using Normalization, of Atrophy, a widely used open-source software, developing a PBVC/y calculator for assessing the deviation from the expected PBVC/y in patients with neurological disorders. We assessed multicenter (34 centers, 11 acquisition protocols) magnetic resonance imaging data of 720 healthy participants covering the whole adult lifespan (16-90 years). Data of 421 participants with a follow-up > 6 months were used to obtain the normative values for PBVC/y and data of 392 participants with a follow-up <1 month were selected to assess the intrasubject variability of the brain volume measurement. A mixed model evaluated PBVC/y dependence on age, sex, and magnetic resonance imaging parameters (scan vendor and magnetic field strength). PBVC/y was associated with age (p < 0.001), with 60- to 70-year-old participants showing twice more volume decrease than participants aged 30-40 years. PBVC/y was also associated with magnetic field strength, with higher decreases when measured by 1.5T than 3T scanners (p < 0.001). The variability of PBVC/y normative percentiles was narrower as the interscan interval was longer (e.g., 80th normative percentile was 50% smaller for participants with 2-year than with 1-year follow-up). The use of these normative data, eased by the freely available calculator, might help in better discriminating pathological from physiological conditions in the clinical setting | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Aging | |
| 650 | 4 | |a Atrophy | |
| 650 | 4 | |a Brain volume | |
| 650 | 4 | |a MRI | |
| 650 | 4 | |a Normative data | |
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| 700 | 1 | |a Luchetti, Ludovico |e verfasserin |4 aut | |
| 700 | 1 | |a Giorgio, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Vrenken, Hugo |e verfasserin |4 aut | |
| 700 | 1 | |a Barkhof, Frederik |e verfasserin |4 aut | |
| 700 | 1 | |a Cover, Keith S |e verfasserin |4 aut | |
| 700 | 1 | |a Bakshi, Rohit |e verfasserin |4 aut | |
| 700 | 1 | |a Chu, Renxin |e verfasserin |4 aut | |
| 700 | 1 | |a Sormani, Maria Pia |e verfasserin |4 aut | |
| 700 | 1 | |a Enzinger, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Ropele, Stefan |e verfasserin |4 aut | |
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| 700 | 1 | |a Rocca, Maria Assunta |e verfasserin |4 aut | |
| 700 | 1 | |a Preziosa, Paolo |e verfasserin |4 aut | |
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| 700 | 1 | |a Kong, Yazhuo |e verfasserin |4 aut | |
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| 700 | 1 | |a De Stefano, Nicola |e verfasserin |4 aut | |
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