Lack of an Association between a Polymorphism in the KRAS 3' Untranslated Region (rs61764370) and Endometriosis in a Large European Case-Control Study
© 2019 S. Karger AG, Basel..
BACKGROUND: Endometriosis is a common disorder that affects 6-10% of reproductive age women. In a previous study, we demonstrated that a polymorphism in let-7 microRNA-binding site in the 3' untranslated region of the KRAS gene was found in 31% of subjects with endometriosis resistant to medical therapy. This polymorphism was now tested in a large, case-control study.
METHODS: Peripheral blood or peritoneal biopsies from 2,077 European subjects with or without endometriosis and known infertility were tested for the presence of the variant allele using polymerase chain reaction.
RESULTS: Histologically proven endometriosis was found in 1,140 subjects, while 937 subjects were disease free. Variant allele carrier rates in subjects with and without endometriosis were 15.7 and 15.1%, respectively. No association between the variant KRAS allele and stage of the disease, age at surgery, body mass index, or type of infertility was identified.
CONCLUSION: A germ-line single-nucleotide polymorphism in the let-7 microRNA-binding site of the KRAS gene was not associated with sporadic endometriosis in an infertile Caucasian population in this large case-control study. However, it remains possible that this gene variant may be a marker of treatment resistance. Further studies on the role of this polymorphism in endometriosis are needed.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:84 |
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| Enthalten in: |
Gynecologic and obstetric investigation - 84(2019), 6 vom: 04., Seite 575-582 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
D'Hooghe, Thomas M [VerfasserIn] |
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| Links: |
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| Themen: |
3' Untranslated Regions |
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| Anmerkungen: |
Date Completed 04.02.2020 Date Revised 07.12.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1159/000500626 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM298024934 |
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| 100 | 1 | |a D'Hooghe, Thomas M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Lack of an Association between a Polymorphism in the KRAS 3' Untranslated Region (rs61764370) and Endometriosis in a Large European Case-Control Study |
| 264 | 1 | |c 2019 | |
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| 500 | |a Date Completed 04.02.2020 | ||
| 500 | |a Date Revised 07.12.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2019 S. Karger AG, Basel. | ||
| 520 | |a BACKGROUND: Endometriosis is a common disorder that affects 6-10% of reproductive age women. In a previous study, we demonstrated that a polymorphism in let-7 microRNA-binding site in the 3' untranslated region of the KRAS gene was found in 31% of subjects with endometriosis resistant to medical therapy. This polymorphism was now tested in a large, case-control study | ||
| 520 | |a METHODS: Peripheral blood or peritoneal biopsies from 2,077 European subjects with or without endometriosis and known infertility were tested for the presence of the variant allele using polymerase chain reaction | ||
| 520 | |a RESULTS: Histologically proven endometriosis was found in 1,140 subjects, while 937 subjects were disease free. Variant allele carrier rates in subjects with and without endometriosis were 15.7 and 15.1%, respectively. No association between the variant KRAS allele and stage of the disease, age at surgery, body mass index, or type of infertility was identified | ||
| 520 | |a CONCLUSION: A germ-line single-nucleotide polymorphism in the let-7 microRNA-binding site of the KRAS gene was not associated with sporadic endometriosis in an infertile Caucasian population in this large case-control study. However, it remains possible that this gene variant may be a marker of treatment resistance. Further studies on the role of this polymorphism in endometriosis are needed | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Endometriosis | |
| 650 | 4 | |a KRAS | |
| 650 | 4 | |a Single-nucleotide polymorphism | |
| 650 | 7 | |a 3' Untranslated Regions |2 NLM | |
| 650 | 7 | |a KRAS protein, human |2 NLM | |
| 650 | 7 | |a MicroRNAs |2 NLM | |
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| 650 | 7 | |a Proto-Oncogene Proteins p21(ras) |2 NLM | |
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| 700 | 1 | |a Grechukhina, Olga |e verfasserin |4 aut | |
| 700 | 1 | |a Cho, SiHyun |e verfasserin |4 aut | |
| 700 | 1 | |a Fassbender, Amelie |e verfasserin |4 aut | |
| 700 | 1 | |a O, Dorien |e verfasserin |4 aut | |
| 700 | 1 | |a Peterse, Daniëlle |e verfasserin |4 aut | |
| 700 | 1 | |a Weidhaas, Joanne |e verfasserin |4 aut | |
| 700 | 1 | |a Taylor, Hugh S |e verfasserin |4 aut | |
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