Six-minute walk test before and after large-volume paracentesis in cirrhotic patients with refractory ascites : A pilot study
Copyright © 2019 Pan-Arab Association of Gastroenterology. Published by Elsevier B.V. All rights reserved..
BACKGROUND/AIMS: Functional impairment is common among cirrhotic patients with refractory ascites, and improvement in functional impairment is an expected issue after paracentesis. The six-minute walk test (6MWT) is considered an objective test for functional activity. No published data have evaluated the 6MWT among cirrhotic patients with refractory ascites before and after large-volume paracentesis. The research aim was to assess the feasibility of performing the 6MWT among cirrhotic patients who had refractory ascites before and after large-volume paracentesis.
MATERIALS AND METHODS: Thirty-one cirrhotic inpatients with refractory ascites were subjected to pulmonary function tests (forced expiratory volume in one second [FEV1], forced vital capacity [FVC], FEV1/FVC) and diffusion lung capacity for carbon monoxide (DLCO) before and 48 h after therapeutic large-volume paracentesis. Dyspnoea as assessed by the Borg scale and functional capacity as assessed by the 6MWT were also evaluated.
RESULTS: Prior to paracentesis, the mean values of FVC and FEV1 were lower than the predicted values, and a significant increase was observed after paracentesis. There was improvement in the mean DLCO values after paracentesis (P < 0.05). Regarding the 6MWT, significant increases in the walked distance (6MWD) (310.7 ± 73 vs. 348.7 ± 72.3 m) and oxygen saturation after paracentesis (P = 0.001) were observed. Significant improvement in the dyspnoea scale also occurred after paracentesis (P = 0.001). A significant positive correlation between the 6MWD before paracentesis and serum albumin levels was demonstrated (r = 0.373, P = 0.039).
CONCLUSION: We found a decrease in pulmonary function and the 6MWD in patients who had refractory ascites, which improved significantly following large-volume paracentesis. The 6MWT is useful in detecting impaired functional capacity among cirrhotic patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
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| Enthalten in: |
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology - 20(2019), 2 vom: 09. Juni, Seite 81-85 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Makhlouf, Nahed A [VerfasserIn] |
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| Links: |
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| Themen: |
6MWT |
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| Anmerkungen: |
Date Completed 13.01.2020 Date Revised 13.01.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ajg.2019.05.009 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM297994131 |
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| 100 | 1 | |a Makhlouf, Nahed A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Six-minute walk test before and after large-volume paracentesis in cirrhotic patients with refractory ascites |b A pilot study |
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| 500 | |a Date Completed 13.01.2020 | ||
| 500 | |a Date Revised 13.01.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019 Pan-Arab Association of Gastroenterology. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a BACKGROUND/AIMS: Functional impairment is common among cirrhotic patients with refractory ascites, and improvement in functional impairment is an expected issue after paracentesis. The six-minute walk test (6MWT) is considered an objective test for functional activity. No published data have evaluated the 6MWT among cirrhotic patients with refractory ascites before and after large-volume paracentesis. The research aim was to assess the feasibility of performing the 6MWT among cirrhotic patients who had refractory ascites before and after large-volume paracentesis | ||
| 520 | |a MATERIALS AND METHODS: Thirty-one cirrhotic inpatients with refractory ascites were subjected to pulmonary function tests (forced expiratory volume in one second [FEV1], forced vital capacity [FVC], FEV1/FVC) and diffusion lung capacity for carbon monoxide (DLCO) before and 48 h after therapeutic large-volume paracentesis. Dyspnoea as assessed by the Borg scale and functional capacity as assessed by the 6MWT were also evaluated | ||
| 520 | |a RESULTS: Prior to paracentesis, the mean values of FVC and FEV1 were lower than the predicted values, and a significant increase was observed after paracentesis. There was improvement in the mean DLCO values after paracentesis (P < 0.05). Regarding the 6MWT, significant increases in the walked distance (6MWD) (310.7 ± 73 vs. 348.7 ± 72.3 m) and oxygen saturation after paracentesis (P = 0.001) were observed. Significant improvement in the dyspnoea scale also occurred after paracentesis (P = 0.001). A significant positive correlation between the 6MWD before paracentesis and serum albumin levels was demonstrated (r = 0.373, P = 0.039) | ||
| 520 | |a CONCLUSION: We found a decrease in pulmonary function and the 6MWD in patients who had refractory ascites, which improved significantly following large-volume paracentesis. The 6MWT is useful in detecting impaired functional capacity among cirrhotic patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a 6MWT | |
| 650 | 4 | |a Cirrhosis | |
| 650 | 4 | |a Paracentesis | |
| 650 | 7 | |a Serum Albumin |2 NLM | |
| 650 | 7 | |a Oxygen |2 NLM | |
| 650 | 7 | |a S88TT14065 |2 NLM | |
| 700 | 1 | |a Mahran, Zainab Gaber |e verfasserin |4 aut | |
| 700 | 1 | |a Sadek, Samiaa Hamdy |e verfasserin |4 aut | |
| 700 | 1 | |a Magdy, Doaa M |e verfasserin |4 aut | |
| 700 | 1 | |a Makhlouf, Hoda A |e verfasserin |4 aut | |
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