Faecal microbiota transplantation for treatment of recurrent or refractory Clostridioides difficile infection in Hong Kong
INTRODUCTION: Clostridioides difficile infection (CDI) is a leading cause of healthcare-associated infection globally, causing significant morbidity and mortality. Faecal microbiota transplantation (FMT) has emerged as a promising option for recurrent and refractory CDI. This study aimed to assess the safety, efficacy, and feasibility of FMT for CDI in Hong Kong.
METHODS: We conducted a single-centre, retrospective study for all consecutive cases of recurrent or refractory CDI who underwent FMT from 2013 to 2018. Clinical demographics, outcome, and safety parameters were collected.
RESULTS: A total of 24 patients with recurrent or refractory CDI (median age 70 years, interquartile range=45.0-78.3 years; 67% male) were included. Over 80% had been recently hospitalised or were long-term care facility residents. Faecal microbiota transplantation was delivered by feeding tube in 11 (45.8%), oesophagogastroduodenoscopy in eight (33.3%), and colonoscopy in six (25%) of the patients. Resolution of diarrhoea without relapse within 8 weeks was achieved in 21 out of 24 patients (87.5%) after FMT. No deaths occurred within 30 days. The FMT was well tolerated and no serious adverse events attributable to FMT were reported.
CONCLUSION: Our results confirm that FMT is a safe, efficacious, and feasible intervention for patients with refractory or recurrent CDI in Hong Kong. Given the increasing disease burden and the lack of effective alternatives in Hong Kong for difficult-to-treat cases of CDI, we recommend that a territory-wide FMT service be established to address increasing demand for this treatment.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2019 |
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Erschienen: |
2019 |
Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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Enthalten in: |
Hong Kong medical journal = Xianggang yi xue za zhi - 25(2019), 3 vom: 09. Juni, Seite 178-182 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Lui, R N [VerfasserIn] |
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Links: |
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Themen: |
Biological specimen banks |
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Anmerkungen: |
Date Completed 08.07.2020 Date Revised 08.07.2020 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.12809/hkmj197855 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM297955810 |
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520 | |a INTRODUCTION: Clostridioides difficile infection (CDI) is a leading cause of healthcare-associated infection globally, causing significant morbidity and mortality. Faecal microbiota transplantation (FMT) has emerged as a promising option for recurrent and refractory CDI. This study aimed to assess the safety, efficacy, and feasibility of FMT for CDI in Hong Kong | ||
520 | |a METHODS: We conducted a single-centre, retrospective study for all consecutive cases of recurrent or refractory CDI who underwent FMT from 2013 to 2018. Clinical demographics, outcome, and safety parameters were collected | ||
520 | |a RESULTS: A total of 24 patients with recurrent or refractory CDI (median age 70 years, interquartile range=45.0-78.3 years; 67% male) were included. Over 80% had been recently hospitalised or were long-term care facility residents. Faecal microbiota transplantation was delivered by feeding tube in 11 (45.8%), oesophagogastroduodenoscopy in eight (33.3%), and colonoscopy in six (25%) of the patients. Resolution of diarrhoea without relapse within 8 weeks was achieved in 21 out of 24 patients (87.5%) after FMT. No deaths occurred within 30 days. The FMT was well tolerated and no serious adverse events attributable to FMT were reported | ||
520 | |a CONCLUSION: Our results confirm that FMT is a safe, efficacious, and feasible intervention for patients with refractory or recurrent CDI in Hong Kong. Given the increasing disease burden and the lack of effective alternatives in Hong Kong for difficult-to-treat cases of CDI, we recommend that a territory-wide FMT service be established to address increasing demand for this treatment | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Biological specimen banks | |
650 | 4 | |a Clostridium difficile | |
650 | 4 | |a Fecal microbiota transplantation | |
700 | 1 | |a Wong, S H |e verfasserin |4 aut | |
700 | 1 | |a Lau, L H S |e verfasserin |4 aut | |
700 | 1 | |a Chan, T T |e verfasserin |4 aut | |
700 | 1 | |a Cheung, K C Y |e verfasserin |4 aut | |
700 | 1 | |a Li, A |e verfasserin |4 aut | |
700 | 1 | |a Chin, M L |e verfasserin |4 aut | |
700 | 1 | |a Tang, W |e verfasserin |4 aut | |
700 | 1 | |a Ching, J Y L |e verfasserin |4 aut | |
700 | 1 | |a Lam, K L Y |e verfasserin |4 aut | |
700 | 1 | |a Chan, P K S |e verfasserin |4 aut | |
700 | 1 | |a Wu, J C Y |e verfasserin |4 aut | |
700 | 1 | |a Sung, J J Y |e verfasserin |4 aut | |
700 | 1 | |a Chan, F K L |e verfasserin |4 aut | |
700 | 1 | |a Ng, S C |e verfasserin |4 aut | |
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