Synthesis and antiviral activity of some imidazo[1,2-b][1,3,4]thiadiazole carbohydrate derivatives
Copyright © 2019 Elsevier Ltd. All rights reserved..
Herein we describe the synthesis of imidazo[2,1-b][1,3,4]thiadiazoles from carbohydrates with D-ribo and D-xylo configuration. The antiviral activity of these compounds was tested against Junín virus (the etiological agent of Argentine hemorrhagic fever). The p-chlorophenyl derivatives showed antiviral activity in a range of micromolar concentration.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:480 |
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| Enthalten in: |
Carbohydrate research - 480(2019) vom: 01. Juli, Seite 61-66 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Fascio, Mirta L [VerfasserIn] |
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| Links: |
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| Themen: |
681HV46001 |
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| Anmerkungen: |
Date Completed 21.11.2019 Date Revised 21.11.2019 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.carres.2019.05.003 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM297933477 |
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| 520 | |a Copyright © 2019 Elsevier Ltd. All rights reserved. | ||
| 520 | |a Herein we describe the synthesis of imidazo[2,1-b][1,3,4]thiadiazoles from carbohydrates with D-ribo and D-xylo configuration. The antiviral activity of these compounds was tested against Junín virus (the etiological agent of Argentine hemorrhagic fever). The p-chlorophenyl derivatives showed antiviral activity in a range of micromolar concentration | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Antiviral activity | |
| 650 | 4 | |a D-Ribo derivatives | |
| 650 | 4 | |a D-Xilo derivatives | |
| 650 | 4 | |a Imidazo[2,1-b][1,3,4]thiadiazole | |
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| 700 | 1 | |a Damonte, Elsa B |e verfasserin |4 aut | |
| 700 | 1 | |a D'Accorso, Norma B |e verfasserin |4 aut | |
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