Liver stiffness assessment by transient elastography suggests high prevalence of liver involvement in common variable immunodeficiency
Copyright © 2019. Published by Elsevier Ltd..
BACKGROUND: Up to 50% of patients with common variable immunodeficiency (CVID) present persistently increased serum levels of liver enzymes and/or mild hepatomegaly. Ultrasound-based transient elastography (TE) is largely used for early detection of the progression of chronic liver diseases, but has never been employed in CVID. We performed a cross-sectional study to evaluate TE values in a cohort of adult CVID-patients.
METHODS: Full blood count, liver function test, liver and spleen sonogram and ultrasound-based TE were performed in 77 adult CVID patients. Demographic and clinical data were retrospectively collected from medical files.
RESULTS: 33.8% (26/77) patients presented increased TE values ranging from moderate fibrosis to cirrhosis. TE values were positively correlated with ALP, γGT, spleen longitudinal diameter and peripheral blood counts (no significant correlation with BMI, AST, ALT, total proteins, albumin, bilirubin and hemoglobin). Moreover, liver stiffness was higher in patients with the clinical phenotypes polyclonal lymphoproliferation and enteropathy, and patients with both these complications had an increased risk (OR: 7.14) of presenting pathologic TE values compared with those without anyone of these.
CONCLUSIONS: Transient elastography is a useful tool to be used alongside clinical and laboratory data to assess liver involvement in CVID.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:51 |
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| Enthalten in: |
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 51(2019), 11 vom: 03. Nov., Seite 1599-1603 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Crescenzi, Ludovica [VerfasserIn] |
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| Links: |
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| Themen: |
Antibody deficiency |
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| Anmerkungen: |
Date Completed 04.06.2020 Date Revised 04.06.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.dld.2019.05.016 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM297730657 |
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| 245 | 1 | 0 | |a Liver stiffness assessment by transient elastography suggests high prevalence of liver involvement in common variable immunodeficiency |
| 264 | 1 | |c 2019 | |
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| 500 | |a Date Completed 04.06.2020 | ||
| 500 | |a Date Revised 04.06.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019. Published by Elsevier Ltd. | ||
| 520 | |a BACKGROUND: Up to 50% of patients with common variable immunodeficiency (CVID) present persistently increased serum levels of liver enzymes and/or mild hepatomegaly. Ultrasound-based transient elastography (TE) is largely used for early detection of the progression of chronic liver diseases, but has never been employed in CVID. We performed a cross-sectional study to evaluate TE values in a cohort of adult CVID-patients | ||
| 520 | |a METHODS: Full blood count, liver function test, liver and spleen sonogram and ultrasound-based TE were performed in 77 adult CVID patients. Demographic and clinical data were retrospectively collected from medical files | ||
| 520 | |a RESULTS: 33.8% (26/77) patients presented increased TE values ranging from moderate fibrosis to cirrhosis. TE values were positively correlated with ALP, γGT, spleen longitudinal diameter and peripheral blood counts (no significant correlation with BMI, AST, ALT, total proteins, albumin, bilirubin and hemoglobin). Moreover, liver stiffness was higher in patients with the clinical phenotypes polyclonal lymphoproliferation and enteropathy, and patients with both these complications had an increased risk (OR: 7.14) of presenting pathologic TE values compared with those without anyone of these | ||
| 520 | |a CONCLUSIONS: Transient elastography is a useful tool to be used alongside clinical and laboratory data to assess liver involvement in CVID | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Antibody deficiency | |
| 650 | 4 | |a Fibroscan | |
| 650 | 4 | |a Primary immunodeficiency | |
| 700 | 1 | |a Pecoraro, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Fiorentino, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Poto, Remo |e verfasserin |4 aut | |
| 700 | 1 | |a Varricchi, Gilda |e verfasserin |4 aut | |
| 700 | 1 | |a Rispo, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Morisco, Filomena |e verfasserin |4 aut | |
| 700 | 1 | |a Spadaro, Giuseppe |e verfasserin |4 aut | |
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