NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death
Copyright © 2019 by The American Association of Immunologists, Inc..
The nucleotide-binding oligomerization domain (NOD)-like receptors belong to the family of pattern recognition receptors (PRRs). NOD-like receptors play a role in regulation of innate immune response by recognition of both pathogen-associated molecular patterns that are engulfed during phagocytic process and danger-associated molecular patterns that are mainly byproducts of cell stress mediated response. NOD-like family pyrin domain containing 6 (NLRP6) is one of the 14 pyrin domain-containing receptors. NLRP6 is highly expressed by epithelial and goblet cells to regulate epithelial renewal and mucus production in mice and humans, but its function in T cells is rather unknown. Increased caspase-1 activation and cell death were observed in mouse Nlrp6-deficient T cells following adoptive transfer into Rag2-deficient mice, indicating that Nlrp6 deficiency in CD4+ T cells led to decreased survival.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:203 |
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| Enthalten in: |
Journal of immunology (Baltimore, Md. : 1950) - 203(2019), 2 vom: 15. Juli, Seite 544-556 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Radulovic, Katarina [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 14.02.2020 Date Revised 14.02.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.4049/jimmunol.1800938 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM297698265 |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019 by The American Association of Immunologists, Inc. | ||
| 520 | |a The nucleotide-binding oligomerization domain (NOD)-like receptors belong to the family of pattern recognition receptors (PRRs). NOD-like receptors play a role in regulation of innate immune response by recognition of both pathogen-associated molecular patterns that are engulfed during phagocytic process and danger-associated molecular patterns that are mainly byproducts of cell stress mediated response. NOD-like family pyrin domain containing 6 (NLRP6) is one of the 14 pyrin domain-containing receptors. NLRP6 is highly expressed by epithelial and goblet cells to regulate epithelial renewal and mucus production in mice and humans, but its function in T cells is rather unknown. Increased caspase-1 activation and cell death were observed in mouse Nlrp6-deficient T cells following adoptive transfer into Rag2-deficient mice, indicating that Nlrp6 deficiency in CD4+ T cells led to decreased survival | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
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| 700 | 1 | |a Ayata, C Korcan |e verfasserin |4 aut | |
| 700 | 1 | |a Mak'Anyengo, Rachel |e verfasserin |4 aut | |
| 700 | 1 | |a Lechner, Kristina |e verfasserin |4 aut | |
| 700 | 1 | |a Wuggenig, Philipp |e verfasserin |4 aut | |
| 700 | 1 | |a Kaya, Berna |e verfasserin |4 aut | |
| 700 | 1 | |a Hruz, Petr |e verfasserin |4 aut | |
| 700 | 1 | |a Gomez de Agüero, Mercedes |e verfasserin |4 aut | |
| 700 | 1 | |a Broz, Petr |e verfasserin |4 aut | |
| 700 | 1 | |a Weigmann, Benno |e verfasserin |4 aut | |
| 700 | 1 | |a Niess, Jan Hendrik |e verfasserin |4 aut | |
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