Different patterns and specific outcomes of large-vessel involvements in giant cell arteritis
Copyright © 2019. Published by Elsevier Ltd..
Large-vessel involvement (LVI) in giant cell arteritis (GCA) includes different clinical and imaging patterns that are rarely described separately at diagnosis and whose specific cardiovascular outcomes are unknown. We conducted a nationwide retrospective study and included GCA patients with LVI demonstrated on imaging at diagnosis between 2007 and 2017. We analyzed the prognosis of three different imaging patterns of LVI present at diagnosis, with some of them overlapping but with the first one present in all patients: 1) inflammation of the aorta and/or its branches; 2) dilation of the aorta; and 3) stenosis of the aortic branches. A control group of GCA patients without LVI was constituted. We included 183 patients with LVI and 105 controls without LVI. Altogether, among the 183 patients who all showed inflammation of the aorta and/or its main branches, concomitant aortic dilation and large-vessel stenosis were observed in 27 (15%) and 55 (30%) patients, respectively. During the follow-up period, new cardiovascular events occurred in 49% and 11% of LVI patients and controls, respectively (p < 0.0001). Inflammation of the aorta and/or its branches (HR: 3.42 [2.09-5.83], p < 0.0001) and large-artery stenosis (HR: 2.75 [1.80-4.15], p < 0.0001) were independent predictive factors of new cardiovascular events. Conversely, the use of an immunosuppressant besides corticosteroids was a protective factor against new cardiovascular events (HR: 0.44 [0.29-0.66], p < 0.0001) and the development of aortic dilation (HR: 0.43 [0.23-0.77], p = 0.005). This study suggests different forms of cardiovascular events according to the initial imaging pattern of LVI.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:103 |
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| Enthalten in: |
Journal of autoimmunity - 103(2019) vom: 11. Sept., Seite 102283 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
de Boysson, Hubert [VerfasserIn] |
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| Links: |
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| Themen: |
Aortic dilation |
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| Anmerkungen: |
Date Completed 21.08.2020 Date Revised 21.08.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jaut.2019.05.011 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM297484656 |
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| 245 | 1 | 0 | |a Different patterns and specific outcomes of large-vessel involvements in giant cell arteritis |
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| 520 | |a Copyright © 2019. Published by Elsevier Ltd. | ||
| 520 | |a Large-vessel involvement (LVI) in giant cell arteritis (GCA) includes different clinical and imaging patterns that are rarely described separately at diagnosis and whose specific cardiovascular outcomes are unknown. We conducted a nationwide retrospective study and included GCA patients with LVI demonstrated on imaging at diagnosis between 2007 and 2017. We analyzed the prognosis of three different imaging patterns of LVI present at diagnosis, with some of them overlapping but with the first one present in all patients: 1) inflammation of the aorta and/or its branches; 2) dilation of the aorta; and 3) stenosis of the aortic branches. A control group of GCA patients without LVI was constituted. We included 183 patients with LVI and 105 controls without LVI. Altogether, among the 183 patients who all showed inflammation of the aorta and/or its main branches, concomitant aortic dilation and large-vessel stenosis were observed in 27 (15%) and 55 (30%) patients, respectively. During the follow-up period, new cardiovascular events occurred in 49% and 11% of LVI patients and controls, respectively (p < 0.0001). Inflammation of the aorta and/or its branches (HR: 3.42 [2.09-5.83], p < 0.0001) and large-artery stenosis (HR: 2.75 [1.80-4.15], p < 0.0001) were independent predictive factors of new cardiovascular events. Conversely, the use of an immunosuppressant besides corticosteroids was a protective factor against new cardiovascular events (HR: 0.44 [0.29-0.66], p < 0.0001) and the development of aortic dilation (HR: 0.43 [0.23-0.77], p = 0.005). This study suggests different forms of cardiovascular events according to the initial imaging pattern of LVI | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Aortic dilation | |
| 650 | 4 | |a Aortic dissection | |
| 650 | 4 | |a Cardiovascular outcomes | |
| 650 | 4 | |a Giant-cell arteritis | |
| 650 | 4 | |a Imaging patterns | |
| 650 | 4 | |a Large-vessel stenosis | |
| 700 | 1 | |a Liozon, Eric |e verfasserin |4 aut | |
| 700 | 1 | |a Espitia, Olivier |e verfasserin |4 aut | |
| 700 | 1 | |a Daumas, Aurélie |e verfasserin |4 aut | |
| 700 | 1 | |a Vautier, Mathieu |e verfasserin |4 aut | |
| 700 | 1 | |a Lambert, Marc |e verfasserin |4 aut | |
| 700 | 1 | |a Parienti, Jean-Jacques |e verfasserin |4 aut | |
| 700 | 1 | |a Granel, Brigitte |e verfasserin |4 aut | |
| 700 | 1 | |a Dumont, Anael |e verfasserin |4 aut | |
| 700 | 1 | |a Sultan, Audrey |e verfasserin |4 aut | |
| 700 | 1 | |a Manrique, Alain |e verfasserin |4 aut | |
| 700 | 1 | |a Saadoun, David |e verfasserin |4 aut | |
| 700 | 1 | |a Ly, Kim Heang |e verfasserin |4 aut | |
| 700 | 1 | |a Agard, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Aouba, Achille |e verfasserin |4 aut | |
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