Ototoxicity of cypermethrin in Wistar rats
Copyright © 2019 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved..
INTRODUCTION: This study presents the effect of cypermethrin on the cochlear function in Wistar rats post-subchronic inhalation exposure. Worldwide several pesticides are described as causing health disorders. Cypermethrin is currently one of the most commonly used, however, little is known about its harmful effects, especially related to hearing. Human studies have associated pesticides with hearing disorders, but they present limited conclusions due to the multiple factors to which the population is exposed, such as noise.
OBJECTIVE: Mimic human exposure to cypermethrin and to verify the effects on cochlear function.
METHODS: It is a subchronic inhalation animal study (6 weeks, 4hours/day), using 36 male Wistar aged 60 day. Rats were randomly assigned into three groups: Control (12 rats exposed to inhalation of water); Positive Control for auditory lesion (12 rats administrated with 24mg/kg intraperitoneal cisplatin); Experimental (12 rats exposed to inhalation of cypermethrin - 0.25mg/L). Animals were evaluated by distortion product otoacoustic emissions pre- and post-exposure.
RESULTS: The frequencies of 8, 10 and 12kHz in both ears (right p=0.003; 0.004; 0.008 and left 0.003; 0.016; 0.005 respectively) and at frequencies 4 and 6 in the right ear (p=0.007 and 0.015, respectively) in the animals exposed to cypermethrin resulted in reduction.
CONCLUSION: Subchronic inhalation exposure to cypermethrin provided ototoxicity in rats.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:86 |
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| Enthalten in: |
Brazilian journal of otorhinolaryngology - 86(2020), 5 vom: 15. Sept., Seite 587-592 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cunha, Eduarda Oliveira [VerfasserIn] |
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| Links: |
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| Themen: |
1TR49121NP |
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| Anmerkungen: |
Date Completed 07.10.2020 Date Revised 02.09.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.bjorl.2019.02.007 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM297410822 |
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| 520 | |a Copyright © 2019 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved. | ||
| 520 | |a INTRODUCTION: This study presents the effect of cypermethrin on the cochlear function in Wistar rats post-subchronic inhalation exposure. Worldwide several pesticides are described as causing health disorders. Cypermethrin is currently one of the most commonly used, however, little is known about its harmful effects, especially related to hearing. Human studies have associated pesticides with hearing disorders, but they present limited conclusions due to the multiple factors to which the population is exposed, such as noise | ||
| 520 | |a OBJECTIVE: Mimic human exposure to cypermethrin and to verify the effects on cochlear function | ||
| 520 | |a METHODS: It is a subchronic inhalation animal study (6 weeks, 4hours/day), using 36 male Wistar aged 60 day. Rats were randomly assigned into three groups: Control (12 rats exposed to inhalation of water); Positive Control for auditory lesion (12 rats administrated with 24mg/kg intraperitoneal cisplatin); Experimental (12 rats exposed to inhalation of cypermethrin - 0.25mg/L). Animals were evaluated by distortion product otoacoustic emissions pre- and post-exposure | ||
| 520 | |a RESULTS: The frequencies of 8, 10 and 12kHz in both ears (right p=0.003; 0.004; 0.008 and left 0.003; 0.016; 0.005 respectively) and at frequencies 4 and 6 in the right ear (p=0.007 and 0.015, respectively) in the animals exposed to cypermethrin resulted in reduction | ||
| 520 | |a CONCLUSION: Subchronic inhalation exposure to cypermethrin provided ototoxicity in rats | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cipermetrina | |
| 650 | 4 | |a Cypermethrin | |
| 650 | 4 | |a Ototoxicidade | |
| 650 | 4 | |a Ototoxicity | |
| 650 | 4 | |a Ratos | |
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| 650 | 7 | |a Cisplatin |2 NLM | |
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| 700 | 1 | |a Machado, Márcia Salgado |e verfasserin |4 aut | |
| 700 | 1 | |a Dallegrave, Eliane |e verfasserin |4 aut | |
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