Diversity, immunoregulatory action and structure-activity relationship of green sea turtle cathelicidins
Copyright © 2019. Published by Elsevier Ltd..
Cathelicidins are a family of gene-encoded immune effectors in vertebrate innate immunity. Here, we reported the diversity and biological activity of cathelicidins in green sea turtle, a marine reptile species known for long lifespan and disease resistance. Four novel cathelicidins (Cm-CATH1-4) were identified from green sea turtle. All of them, especially Cm-CATH2, exhibited potent, broad-spectrum and rapid bactericidal and anti-biofilm activities by inducing the disruption of cell membrane integrity. Additionally, Cm-CATH2 effectively induced the macrophages/monocytes and neutrophils trafficking to the infection site, and inhibited the LPS-induced production of inflammatory cytokines, by blocking TLR4/MD2 complex and the downstream signaling pathway activation. In mouse peritonitis and pneumonia models, Cm-CATH2 exhibited evident protection against drug-resistant bacterial infections. Taken together, the diverse structures and functions of Cm-CATHs indicated their pleiotropic role in innate immunity of green sea turtle, and the potent antimicrobial, anti-biofilm and immunomodulatory properties make them ideal candidates for the development of novel anti-infective drugs.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:98 |
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| Enthalten in: |
Developmental and comparative immunology - 98(2019) vom: 12. Sept., Seite 189-204 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Qiao, Xue [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-Infective Agents |
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| Anmerkungen: |
Date Completed 03.02.2020 Date Revised 03.02.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.dci.2019.05.005 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM297394037 |
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| 245 | 1 | 0 | |a Diversity, immunoregulatory action and structure-activity relationship of green sea turtle cathelicidins |
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| 500 | |a Date Revised 03.02.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019. Published by Elsevier Ltd. | ||
| 520 | |a Cathelicidins are a family of gene-encoded immune effectors in vertebrate innate immunity. Here, we reported the diversity and biological activity of cathelicidins in green sea turtle, a marine reptile species known for long lifespan and disease resistance. Four novel cathelicidins (Cm-CATH1-4) were identified from green sea turtle. All of them, especially Cm-CATH2, exhibited potent, broad-spectrum and rapid bactericidal and anti-biofilm activities by inducing the disruption of cell membrane integrity. Additionally, Cm-CATH2 effectively induced the macrophages/monocytes and neutrophils trafficking to the infection site, and inhibited the LPS-induced production of inflammatory cytokines, by blocking TLR4/MD2 complex and the downstream signaling pathway activation. In mouse peritonitis and pneumonia models, Cm-CATH2 exhibited evident protection against drug-resistant bacterial infections. Taken together, the diverse structures and functions of Cm-CATHs indicated their pleiotropic role in innate immunity of green sea turtle, and the potent antimicrobial, anti-biofilm and immunomodulatory properties make them ideal candidates for the development of novel anti-infective drugs | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Antimicrobial | |
| 650 | 4 | |a Cathelicidin | |
| 650 | 4 | |a Chelonia mydas | |
| 650 | 4 | |a Host defense peptides (HDPs) | |
| 650 | 4 | |a Immunomodulatory | |
| 650 | 4 | |a TLR4-MD2 complex | |
| 650 | 7 | |a Anti-Infective Agents |2 NLM | |
| 650 | 7 | |a Cathelicidins |2 NLM | |
| 700 | 1 | |a Yang, Huaixin |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Jiuxiang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Fen |e verfasserin |4 aut | |
| 700 | 1 | |a Chu, Peng |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Yongliang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Minghui |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yipeng |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Haining |e verfasserin |4 aut | |
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