The dominant role of surface functionalization in carbon dots' photo-activated antibacterial activity
Background: Carbon dots (CDots) have recently been demonstrated their effective visible light-activated antimicrobial activities toward bacteria. This study was to evaluate and understand the roles of the surface functionalities in governing the antimicrobial activity of CDots. Methods: Using the laboratory model bacteria Bacillus subtilis, the photo-activated antimicrobial activities of three groups of CDots with specifically selected different surface functionalization moieties were evaluated and compared. The first group consisting of CDots with surface functionalization by 2,2-(ethylenedioxy)bis(ethylamine) (EDA) vs. 3-ethoxypropylamine (EPA), was evaluated to determine the effect of different terminal groups/charges on their photo-activated antibacterial activities. The second group consisting of CDots functionalized with oligomeric polyethylenimine (PEI) and those prepared by the carbonization of PEI - citric acid mixture, was to evaluate the effects of dot surface charges vs. fluorescent quantum yields on their antimicrobial activities. The third group consisting of CDots functionalized with PEI of 1,200 vs. 600 in average molecular weight was evaluated for the effect of molecular weight of surface passivation molecular on their antimicrobial activities. Results: The results indicated the EDA-CDots in the first group was more effective and was attributed to the positive charges from the protonation of the amino groups (-NH2) being more favorable to interactions with bacterial cells. The evaluation of the second group CDots suggested the same surface charge effect dominating the antibacterial performance over the fluorescent quantum yields. The evaluation of the third group CDots functionalized with PEI of 1,200 vs. 600 in average molecular weight, indicated the latter was significantly more effective. Conclusions: The results from this study highlighted the dominant role of surface functionalities in governing CDots' light activated antimicrobial activity and should have significant implications to the further design and development of CDots as a new class of visible light-activated antibacterial agents.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
International journal of nanomedicine - 14(2019) vom: 01., Seite 2655-2665 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Abu Rabe, Dina I [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 12.07.2019 Date Revised 11.10.2023 published: Electronic-eCollection Citation Status MEDLINE |
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| doi: |
10.2147/IJN.S200493 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM297368575 |
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| 100 | 1 | |a Abu Rabe, Dina I |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a The dominant role of surface functionalization in carbon dots' photo-activated antibacterial activity |
| 264 | 1 | |c 2019 | |
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| 500 | |a Date Completed 12.07.2019 | ||
| 500 | |a Date Revised 11.10.2023 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Background: Carbon dots (CDots) have recently been demonstrated their effective visible light-activated antimicrobial activities toward bacteria. This study was to evaluate and understand the roles of the surface functionalities in governing the antimicrobial activity of CDots. Methods: Using the laboratory model bacteria Bacillus subtilis, the photo-activated antimicrobial activities of three groups of CDots with specifically selected different surface functionalization moieties were evaluated and compared. The first group consisting of CDots with surface functionalization by 2,2-(ethylenedioxy)bis(ethylamine) (EDA) vs. 3-ethoxypropylamine (EPA), was evaluated to determine the effect of different terminal groups/charges on their photo-activated antibacterial activities. The second group consisting of CDots functionalized with oligomeric polyethylenimine (PEI) and those prepared by the carbonization of PEI - citric acid mixture, was to evaluate the effects of dot surface charges vs. fluorescent quantum yields on their antimicrobial activities. The third group consisting of CDots functionalized with PEI of 1,200 vs. 600 in average molecular weight was evaluated for the effect of molecular weight of surface passivation molecular on their antimicrobial activities. Results: The results indicated the EDA-CDots in the first group was more effective and was attributed to the positive charges from the protonation of the amino groups (-NH2) being more favorable to interactions with bacterial cells. The evaluation of the second group CDots suggested the same surface charge effect dominating the antibacterial performance over the fluorescent quantum yields. The evaluation of the third group CDots functionalized with PEI of 1,200 vs. 600 in average molecular weight, indicated the latter was significantly more effective. Conclusions: The results from this study highlighted the dominant role of surface functionalities in governing CDots' light activated antimicrobial activity and should have significant implications to the further design and development of CDots as a new class of visible light-activated antibacterial agents | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a carbon dots | |
| 650 | 4 | |a photo-activated | |
| 650 | 4 | |a surface functionalization | |
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| 650 | 7 | |a Ethylamines |2 NLM | |
| 650 | 7 | |a Propylamines |2 NLM | |
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| 700 | 1 | |a Al Awak, Mohamad M |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Fan |e verfasserin |4 aut | |
| 700 | 1 | |a Okonjo, Peter A |e verfasserin |4 aut | |
| 700 | 1 | |a Dong, Xiuli |e verfasserin |4 aut | |
| 700 | 1 | |a Teisl, Lindsay R |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Ping |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Yongan |e verfasserin |4 aut | |
| 700 | 1 | |a Pan, Nengyu |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Ya-Ping |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Liju |e verfasserin |4 aut | |
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