Metastasis Organotropism : Redefining the Congenial Soil
Copyright © 2019 Elsevier Inc. All rights reserved..
Metastasis is the most devastating stage of cancer progression and causes the majority of cancer-related deaths. Clinical observations suggest that most cancers metastasize to specific organs, a process known as "organotropism." Elucidating the underlying mechanisms may help identify targets and treatment strategies to benefit patients. This review summarizes recent findings on tumor-intrinsic properties and their interaction with unique features of host organs, which together determine organ-specific metastatic behaviors. Emerging insights related to the roles of metabolic changes, the immune landscapes of target organs, and variation in epithelial-mesenchymal transitions open avenues for future studies of metastasis organotropism.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:49 |
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| Enthalten in: |
Developmental cell - 49(2019), 3 vom: 06. Mai, Seite 375-391 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gao, Yang [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 06.01.2020 Date Revised 11.10.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1016/j.devcel.2019.04.012 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM296831514 |
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| 520 | |a Metastasis is the most devastating stage of cancer progression and causes the majority of cancer-related deaths. Clinical observations suggest that most cancers metastasize to specific organs, a process known as "organotropism." Elucidating the underlying mechanisms may help identify targets and treatment strategies to benefit patients. This review summarizes recent findings on tumor-intrinsic properties and their interaction with unique features of host organs, which together determine organ-specific metastatic behaviors. Emerging insights related to the roles of metabolic changes, the immune landscapes of target organs, and variation in epithelial-mesenchymal transitions open avenues for future studies of metastasis organotropism | ||
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| 700 | 1 | |a Rosen, Jeffrey M |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xiang H-F |e verfasserin |4 aut | |
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