Urate and risk of Alzheimer's disease and vascular dementia : A population-based study
Copyright © 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved..
INTRODUCTION: Low serum urate (sU) has been suggested to increase the risk of dementia since a reduction might impair antioxidant capacity. On the other hand, high sU is associated with increased cardiovascular risk which might increase the risk of dementia, especially for vascular dementia.
METHODS: In 1968-1969, a population-based sample of 1462 women aged 38 to 60 years was examined and were followed up over 44 years (mean 33.1 years). We examined whether sU (determined in 1968-1969 and 1992-1994) is associated with risk of late-life dementia.
RESULTS: During 44 years of follow-up, a higher sU (per standard deviation of 76.5 μmol/L) was associated with lower risk for dementia (n = 320; hazard ratio [HR] 0.81; confidence interval [CI] 0.72-0.91), Alzheimer's disease (n = 152; HR 0.78; CI 0.66-0.91), and vascular dementia (n = 52; HR 0.66; CI 0.47-0.94).
DISCUSSION: Our findings support the hypothesis that sU has a protective role in the development of dementia, regardless of dementia subtype. This may have important implications in the treatment of dementia and treatment goals for hyperuricemia in patients with gout.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Alzheimer's & dementia : the journal of the Alzheimer's Association - 15(2019), 6 vom: 15. Juni, Seite 754-763 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Scheepers, Lieke E J M [VerfasserIn] |
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| Links: |
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| Themen: |
268B43MJ25 |
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| Anmerkungen: |
Date Completed 22.06.2020 Date Revised 22.06.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jalz.2019.01.014 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM296758469 |
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| 100 | 1 | |a Scheepers, Lieke E J M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Urate and risk of Alzheimer's disease and vascular dementia |b A population-based study |
| 264 | 1 | |c 2019 | |
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| 500 | |a Date Completed 22.06.2020 | ||
| 500 | |a Date Revised 22.06.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a INTRODUCTION: Low serum urate (sU) has been suggested to increase the risk of dementia since a reduction might impair antioxidant capacity. On the other hand, high sU is associated with increased cardiovascular risk which might increase the risk of dementia, especially for vascular dementia | ||
| 520 | |a METHODS: In 1968-1969, a population-based sample of 1462 women aged 38 to 60 years was examined and were followed up over 44 years (mean 33.1 years). We examined whether sU (determined in 1968-1969 and 1992-1994) is associated with risk of late-life dementia | ||
| 520 | |a RESULTS: During 44 years of follow-up, a higher sU (per standard deviation of 76.5 μmol/L) was associated with lower risk for dementia (n = 320; hazard ratio [HR] 0.81; confidence interval [CI] 0.72-0.91), Alzheimer's disease (n = 152; HR 0.78; CI 0.66-0.91), and vascular dementia (n = 52; HR 0.66; CI 0.47-0.94) | ||
| 520 | |a DISCUSSION: Our findings support the hypothesis that sU has a protective role in the development of dementia, regardless of dementia subtype. This may have important implications in the treatment of dementia and treatment goals for hyperuricemia in patients with gout | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Alzheimer's disease | |
| 650 | 4 | |a Epidemiology | |
| 650 | 4 | |a Oxidative stress | |
| 650 | 4 | |a Urate | |
| 650 | 4 | |a Vascular dementia | |
| 650 | 7 | |a Uric Acid |2 NLM | |
| 650 | 7 | |a 268B43MJ25 |2 NLM | |
| 700 | 1 | |a Jacobsson, Lennart T H |e verfasserin |4 aut | |
| 700 | 1 | |a Kern, Silke |e verfasserin |4 aut | |
| 700 | 1 | |a Johansson, Lena |e verfasserin |4 aut | |
| 700 | 1 | |a Dehlin, Mats |e verfasserin |4 aut | |
| 700 | 1 | |a Skoog, Ingmar |e verfasserin |4 aut | |
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