Understanding the spatial distribution of trichiasis and its association with trachomatous inflammation-follicular
BACKGROUND: Whilst previous work has identified clustering of the active trachoma sign "trachomatous inflammation-follicular" (TF), there is limited understanding of the spatial structure of trachomatous trichiasis (TT), the rarer, end-stage, blinding form of disease. Here we use community-level TF prevalence, information on access to water and sanitation, and large-scale environmental and socio-economic indicators to model the spatial variation in community-level TT prevalence in Benin, Cote d'Ivoire, DRC, Guinea, Ethiopia, Malawi, Mozambique, Nigeria, Sudan and Uganda.
METHODS: We fit binomial mixed models, with community-level random effects, separately for each country. In countries where spatial correlation was detected through a semi-variogram diagnostic check we then fitted a geostatistical model to the TT prevalence data including TF prevalence as an explanatory variable.
RESULTS: The estimated regression relationship between community-level TF and TT was significant in eight countries. We estimate that a 10% increase in community-level TF prevalence leads to an increase in the odds for TT ranging from 20 to 86% when accounting for additional covariates.
CONCLUSION: We find evidence of an association between TF and TT in some parts of Africa. However, our results also suggest the presence of additional, country-specific, spatial risk factors which modulate the variation in TT risk.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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| Enthalten in: |
BMC infectious diseases - 19(2019), 1 vom: 30. Apr., Seite 364 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Flueckiger, Rebecca Mann [VerfasserIn] |
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| Links: |
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| Themen: |
Blindness |
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| Anmerkungen: |
Date Completed 18.06.2019 Date Revised 25.02.2020 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12879-019-3935-1 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM296594881 |
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| 100 | 1 | |a Flueckiger, Rebecca Mann |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Understanding the spatial distribution of trichiasis and its association with trachomatous inflammation-follicular |
| 264 | 1 | |c 2019 | |
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| 500 | |a Date Completed 18.06.2019 | ||
| 500 | |a Date Revised 25.02.2020 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Whilst previous work has identified clustering of the active trachoma sign "trachomatous inflammation-follicular" (TF), there is limited understanding of the spatial structure of trachomatous trichiasis (TT), the rarer, end-stage, blinding form of disease. Here we use community-level TF prevalence, information on access to water and sanitation, and large-scale environmental and socio-economic indicators to model the spatial variation in community-level TT prevalence in Benin, Cote d'Ivoire, DRC, Guinea, Ethiopia, Malawi, Mozambique, Nigeria, Sudan and Uganda | ||
| 520 | |a METHODS: We fit binomial mixed models, with community-level random effects, separately for each country. In countries where spatial correlation was detected through a semi-variogram diagnostic check we then fitted a geostatistical model to the TT prevalence data including TF prevalence as an explanatory variable | ||
| 520 | |a RESULTS: The estimated regression relationship between community-level TF and TT was significant in eight countries. We estimate that a 10% increase in community-level TF prevalence leads to an increase in the odds for TT ranging from 20 to 86% when accounting for additional covariates | ||
| 520 | |a CONCLUSION: We find evidence of an association between TF and TT in some parts of Africa. However, our results also suggest the presence of additional, country-specific, spatial risk factors which modulate the variation in TT risk | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Blindness | |
| 650 | 4 | |a Epidemiology | |
| 650 | 4 | |a Global trachoma mapping project | |
| 650 | 4 | |a Neglected tropical disease | |
| 650 | 4 | |a Trachoma | |
| 650 | 4 | |a Trichiasis | |
| 650 | 4 | |a Visual impairment | |
| 700 | 1 | |a Giorgi, Emanuele |e verfasserin |4 aut | |
| 700 | 1 | |a Cano, Jorge |e verfasserin |4 aut | |
| 700 | 1 | |a Abdala, Mariamo |e verfasserin |4 aut | |
| 700 | 1 | |a Amiel, Olga Nelson |e verfasserin |4 aut | |
| 700 | 1 | |a Baayenda, Gilbert |e verfasserin |4 aut | |
| 700 | 1 | |a Bakhtiari, Ana |e verfasserin |4 aut | |
| 700 | 1 | |a Batcho, Wilfrid |e verfasserin |4 aut | |
| 700 | 1 | |a Bennawi, Kamal Hashim |e verfasserin |4 aut | |
| 700 | 1 | |a Dejene, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Elshafie, Balgesa Elkheir |e verfasserin |4 aut | |
| 700 | 1 | |a Elvis, Aba Ange |e verfasserin |4 aut | |
| 700 | 1 | |a François, Missamou |e verfasserin |4 aut | |
| 700 | 1 | |a Goepogui, André |e verfasserin |4 aut | |
| 700 | 1 | |a Kalua, Khumbo |e verfasserin |4 aut | |
| 700 | 1 | |a Kebede, Biruck |e verfasserin |4 aut | |
| 700 | 1 | |a Kiflu, Genet |e verfasserin |4 aut | |
| 700 | 1 | |a Masika, Michael P |e verfasserin |4 aut | |
| 700 | 1 | |a Massangaie, Marilia |e verfasserin |4 aut | |
| 700 | 1 | |a Mpyet, Caleb |e verfasserin |4 aut | |
| 700 | 1 | |a Ndjemba, Jean |e verfasserin |4 aut | |
| 700 | 1 | |a Ngondi, Jeremiah M |e verfasserin |4 aut | |
| 700 | 1 | |a Olobio, Nicholas |e verfasserin |4 aut | |
| 700 | 1 | |a Turyaguma, Patrick |e verfasserin |4 aut | |
| 700 | 1 | |a Willis, Rebecca |e verfasserin |4 aut | |
| 700 | 1 | |a Yeo, Souleymane |e verfasserin |4 aut | |
| 700 | 1 | |a Solomon, Anthony W |e verfasserin |4 aut | |
| 700 | 1 | |a Pullan, Rachel L |e verfasserin |4 aut | |
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