Lymphocytes upregulate CD36 in adipose tissue and liver
CD36 is a multifunctional scavenger receptor and lipid transporter implicated in metabolic and inflammatory pathologies, as well as cancer progression. CD36 is known to be expressed by adipocytes and monocytes/macrophages, but its expression by T cells is not clearly established. We found that CD4 and CD8 T cells in adipose tissue and liver of humans, monkeys, and mice upregulated CD36 expression (ranging from ~5-40% CD36+), whereas little to no CD36 was expressed by T cells in blood, spleen, and lymph nodes. CD36 was expressed predominantly by resting CD38-, HLA.DR-, and PD-1- adipose tissue T cells in monkeys, and increased during high-fat feeding in mice. Adipose tissue and liver promote a distinct phenotype in resident T cells characterized by CD36 upregulation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
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| Enthalten in: |
Adipocyte - 8(2019), 1 vom: 29. Dez., Seite 154-163 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Couturier, Jacob [VerfasserIn] |
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| Links: |
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| Themen: |
Adipose tissue |
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| Anmerkungen: |
Date Completed 10.04.2020 Date Revised 13.12.2020 published: Print Citation Status MEDLINE |
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| doi: |
10.1080/21623945.2019.1609202 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM296556858 |
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| 520 | |a CD36 is a multifunctional scavenger receptor and lipid transporter implicated in metabolic and inflammatory pathologies, as well as cancer progression. CD36 is known to be expressed by adipocytes and monocytes/macrophages, but its expression by T cells is not clearly established. We found that CD4 and CD8 T cells in adipose tissue and liver of humans, monkeys, and mice upregulated CD36 expression (ranging from ~5-40% CD36+), whereas little to no CD36 was expressed by T cells in blood, spleen, and lymph nodes. CD36 was expressed predominantly by resting CD38-, HLA.DR-, and PD-1- adipose tissue T cells in monkeys, and increased during high-fat feeding in mice. Adipose tissue and liver promote a distinct phenotype in resident T cells characterized by CD36 upregulation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Adipose tissue | |
| 650 | 4 | |a CD36 | |
| 650 | 4 | |a T cells | |
| 650 | 4 | |a metabolism | |
| 650 | 4 | |a obesity | |
| 650 | 7 | |a CD36 Antigens |2 NLM | |
| 700 | 1 | |a Nuotio-Antar, Alli M |e verfasserin |4 aut | |
| 700 | 1 | |a Agarwal, Neeti |e verfasserin |4 aut | |
| 700 | 1 | |a Wilkerson, Gregory K |e verfasserin |4 aut | |
| 700 | 1 | |a Saha, Pradip |e verfasserin |4 aut | |
| 700 | 1 | |a Kulkarni, Viraj |e verfasserin |4 aut | |
| 700 | 1 | |a Lakhashe, Samir K |e verfasserin |4 aut | |
| 700 | 1 | |a Esquivel, Juan |e verfasserin |4 aut | |
| 700 | 1 | |a Nehete, Pramod N |e verfasserin |4 aut | |
| 700 | 1 | |a Ruprecht, Ruth M |e verfasserin |4 aut | |
| 700 | 1 | |a Sastry, K Jagannadha |e verfasserin |4 aut | |
| 700 | 1 | |a Meyer, Jennifer M |e verfasserin |4 aut | |
| 700 | 1 | |a Hill, Lori R |e verfasserin |4 aut | |
| 700 | 1 | |a Lake, Jordan E |e verfasserin |4 aut | |
| 700 | 1 | |a Balasubramanyam, Ashok |e verfasserin |4 aut | |
| 700 | 1 | |a Lewis, Dorothy E |e verfasserin |4 aut | |
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