Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection
Copyright © 2019 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved..
Plasmin(ogen) acquisition is critical for invasive disease initiation by Streptococcus pyogenes (GAS). Host urokinase plasminogen activator (uPA) plays a role in mediating plasminogen activation for GAS dissemination, however the contribution of tissue-type plasminogen activator (tPA) to GAS virulence is unknown. Using novel tPA-deficient ALBPLG1 mice, our study revealed no difference in mouse survival, bacterial dissemination or the pathology of GAS infection in the absence of tPA in AlbPLG1/tPA-/- mice compared to AlbPLG1 mice. This study suggests that tPA has a limited role in this humanized model of GAS infection, further highlighting the importance of its counterpart uPA in GAS disease.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2019 |
|---|---|
| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
|---|---|
| Enthalten in: |
Microbes and infection - 21(2019), 8-9 vom: 28. Okt., Seite 412-417 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Ly, Diane [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 06.02.2020 Date Revised 16.04.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.micinf.2019.04.004 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM296302007 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM296302007 | ||
| 003 | DE-627 | ||
| 005 | 20240416232110.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.micinf.2019.04.004 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1377.xml |
| 035 | |a (DE-627)NLM296302007 | ||
| 035 | |a (NLM)31009808 | ||
| 035 | |a (PII)S1286-4579(19)30051-6 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Ly, Diane |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 06.02.2020 | ||
| 500 | |a Date Revised 16.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2019 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved. | ||
| 520 | |a Plasmin(ogen) acquisition is critical for invasive disease initiation by Streptococcus pyogenes (GAS). Host urokinase plasminogen activator (uPA) plays a role in mediating plasminogen activation for GAS dissemination, however the contribution of tissue-type plasminogen activator (tPA) to GAS virulence is unknown. Using novel tPA-deficient ALBPLG1 mice, our study revealed no difference in mouse survival, bacterial dissemination or the pathology of GAS infection in the absence of tPA in AlbPLG1/tPA-/- mice compared to AlbPLG1 mice. This study suggests that tPA has a limited role in this humanized model of GAS infection, further highlighting the importance of its counterpart uPA in GAS disease | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Animal infection model | |
| 650 | 4 | |a Plasminogen | |
| 650 | 4 | |a Streptococcus pyogenes | |
| 650 | 4 | |a Streptokinase | |
| 650 | 4 | |a Tissue-type plasminogen activator (tPA) | |
| 650 | 4 | |a Urokinase plasminogen activator (uPA) | |
| 650 | 7 | |a PLAT protein, human |2 NLM | |
| 650 | 7 | |a EC 3.4.21.68 |2 NLM | |
| 650 | 7 | |a Tissue Plasminogen Activator |2 NLM | |
| 650 | 7 | |a EC 3.4.21.68 |2 NLM | |
| 700 | 1 | |a Donahue, Deborah |e verfasserin |4 aut | |
| 700 | 1 | |a Walker, Mark J |e verfasserin |4 aut | |
| 700 | 1 | |a Ploplis, Victoria A |e verfasserin |4 aut | |
| 700 | 1 | |a McArthur, Jason D |e verfasserin |4 aut | |
| 700 | 1 | |a Ranson, Marie |e verfasserin |4 aut | |
| 700 | 1 | |a Castellino, Francis J |e verfasserin |4 aut | |
| 700 | 1 | |a Sanderson-Smith, Martina L |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Microbes and infection |d 1999 |g 21(2019), 8-9 vom: 28. Okt., Seite 412-417 |w (DE-627)NLM105022780 |x 1769-714X |7 nnns |
| 773 | 1 | 8 | |g volume:21 |g year:2019 |g number:8-9 |g day:28 |g month:10 |g pages:412-417 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.micinf.2019.04.004 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 21 |j 2019 |e 8-9 |b 28 |c 10 |h 412-417 | ||